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  Activation of SC during electrical stimulation of LGN: retinal antidromic stimulation or corticocollicular activation?

Murayama, Y., Augath, M., & Logothetis, N. (2011). Activation of SC during electrical stimulation of LGN: retinal antidromic stimulation or corticocollicular activation? Magnetic Resonance Imaging, 29(10), 1351-1357. doi:10.1016/j.mri.2011.08.002.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-B8AE-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-ACD5-D
Genre: Journal Article

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Murayama, Y1, 2, Author              
Augath, M1, 2, Author              
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: We have recently used combined electrostimulation, neurophysiology, microinjection and functional magnetic resonance imaging (fMRI) to study the cortical activity patterns elicited during stimulation of cortical afferents in monkeys. We found that stimulation of a site in lateral geniculate nucleus (LGN) increases the fMRI signal in the regions of primary visual cortex receiving input from that site, but suppresses it in the retinotopically matched regions of extrastriate cortex. Intracortical injection experiments showed that such suppression is due to synaptic inhibition. During these experiments, we have consistently observed activation of superior colliculus (SC) following LGN stimulation. Since LGN does not directly project to SC, the current study investigated the origin of SC activation. By examining experimental manipulations inactivating the primary visual cortex, we present here evidence that the robust SC activation, which follows the stimulation of LGN, is due to the activation of corticocollicular pathway.

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 Dates: 2011-12
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.mri.2011.08.002
BibTex Citekey: MurayamaAL2011
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Title: Magnetic Resonance Imaging
Source Genre: Journal
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Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 29 (10) Sequence Number: - Start / End Page: 1351 - 1357 Identifier: ISSN: 0730-725X
CoNE: /journals/resource/954925533026