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  Acute ketamine administration modulates glutamatergic neurotransmission and functional brain activation in prefrontal cortex implications for major depression

Scheidegger, M., Henning, A., Walter, M., Fuchs, A., Krähenmann, R., Böker, H., et al. (2011). Acute ketamine administration modulates glutamatergic neurotransmission and functional brain activation in prefrontal cortex implications for major depression. Pharmacopsychiatry, 21(6), A98.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-B8E6-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-5236-5
Genre: Meeting Abstract

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 Creators:
Scheidegger, M, Author
Henning, A1, Author              
Walter, M, Author              
Fuchs, A, Author
Krähenmann, R, Author
Böker, H, Author
Bösiger, P, Author
Seifritz, E, Author
Grimm, S, Author
Affiliations:
1Institute for Biomedical Engineering UZH and ETH Zürich, ou_persistent22              

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 Abstract: Background: Ketamine is a potent NMDA receptor antagonist with rapid antidepressant properties at subanaesthetic doses. This multimodal imaging study reveals the effects of a subanaesthetic ketamine infusion on fMRI-BOLD responses during an emotional processing task and their relationship to glutamatergic metabolite concentrations in the pregenual anterior cingulate cortex (PACC) assessed by proton magnetic resonance spectroscopy (1H-MRS). Methods: 23 healthy subjects were asked to judge photographs from the International Affective Picture System (IAPS) by button press according to their valence in two separate fMRI sessions (baseline/ketamine) on a Philips 3T MR unit. S-ketamine was administered as an i.v. bolus of 0.12 mg/kg, followed by an infusion of 0.25 mg/kg/h over 60 min. 1H-MRS spectra from the bilateral PACC could be obtained in 16 subjects immediately after the task using a JPRESS sequence. Results and Conclusion: In the PACC, changes in NBRs correlated with glutamine to glutamate ratios as a putative marker of glutamatergic neurotransmission after ketamine administration compared to baseline. These changes are most likely interpreted in terms of an increased glutamate-glutamine-cycling rate after ketamine administration. Thus, the antidepressant effect of ketamine might be linked to a beneficial short-term influence on glutamatergic neurotransmission.

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 Dates: 2011-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1055/s-0031-1292539
BibTex Citekey: ScheideggerHWFKBBSG2011
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Title: 27. Symposium der Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP)
Place of Event: München, Germany
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Title: Pharmacopsychiatry
Source Genre: Journal
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Publ. Info: Stuttgart : Thieme
Pages: - Volume / Issue: 21 (6) Sequence Number: - Start / End Page: A98 Identifier: ISSN: 0176-3679
CoNE: https://pure.mpg.de/cone/journals/resource/954925487778