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  Whole-genome sequencing of multiple Arabidopsis thaliana populations

Cao, J., Schneeberger, K., Ossowski, S., Günther, T., Bender, S., Fitz, J., et al. (2011). Whole-genome sequencing of multiple Arabidopsis thaliana populations. Nature Genetics, 43(10), 956-963. doi:10.1038/ng.911.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-B99E-B Version Permalink: http://hdl.handle.net/21.11116/0000-0006-C590-8
Genre: Journal Article

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https://www.nature.com/articles/ng.911.pdf (Publisher version)
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 Creators:
Cao, J, Author
Schneeberger, K, Author
Ossowski , S, Author
Günther, T, Author
Bender , S, Author
Fitz, J, Author
Koenig, D, Author
Lanz, C, Author
Stegle, O1, Author              
Lippert, C1, Author              
Wang, X, Author
Ott, F, Author
Müller, J, Author
Alonso-Blanco, C, Author
Borgwardt, K1, Author              
Schmid, KJ, Author
Weigel, D2, Author              
Affiliations:
1Former Research Group Machine Learning and Computational Biology, Max Planck Institute for Intelligent Systems, Max Planck Society, DE, ou_1497664              
2Max Planck Institute for Developmental Biology, Max Planck Society, Max-Planck-Ring 5, 72076 Tübingen, DE, ou_2421691              

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 Abstract: The plant Arabidopsis thaliana occurs naturally in many different habitats throughout Eurasia. As a foundation for identifying genetic variation contributing to adaptation to diverse environments, a 1001 Genomes Project to sequence geographically diverse A. thaliana strains has been initiated. Here we present the first phase of this project, based on population-scale sequencing of 80 strains drawn from eight regions throughout the species' native range. We describe the majority of common small-scale polymorphisms as well as many larger insertions and deletions in the A. thaliana pan-genome, their effects on gene function, and the patterns of local and global linkage among these variants. The action of processes other than spontaneous mutation is identified by comparing the spectrum of mutations that have accumulated since A. thaliana diverged from its closest relative 10 million years ago with the spectrum observed in the laboratory. Recent species-wide selective sweeps are rare, and potentially deleterious mutations are more common in marginal populations.

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 Dates: 2011-10
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1038/ng.911
BibTex Citekey: CaoSOGBFKLSLWOMABSW2012
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Title: Nature Genetics
  Other : Nature Genet.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America, Inc.
Pages: - Volume / Issue: 43 (10) Sequence Number: - Start / End Page: 956 - 963 Identifier: ISSN: 1061-4036
CoNE: https://pure.mpg.de/cone/journals/resource/954925598609