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  MRI-Based Attenuation Correction for Whole-Body PET/MRI: Quantitative Evaluation of Segmentation- and Atlas-Based Methods

Hofmann, M., Bezrukov, I., Mantlik, F., Aschoff, B., Steinke, F., Beyer, T., et al. (2011). MRI-Based Attenuation Correction for Whole-Body PET/MRI: Quantitative Evaluation of Segmentation- and Atlas-Based Methods. Journal of Nuclear Medicine, 52(9), 1392-1399. doi:10.2967/jnumed.110.078949.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-BA26-D Version Permalink: http://hdl.handle.net/21.11116/0000-0001-B1D1-A
Genre: Journal Article

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 Creators:
Hofmann, M1, Author              
Bezrukov, I1, Author              
Mantlik, F1, Author              
Aschoff, B, Author
Steinke, F1, Author              
Beyer, T, Author
Pichler, BJ, Author
Schölkopf, B1, Author              
Affiliations:
1Dept. Empirical Inference, Max Planck Institute for Intelligent Systems, Max Planck Society, ou_1497647              

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 Abstract: PET/MRI is an emerging dual-modality imaging technology that requires new approaches to PET attenuation correction (AC). We assessed 2 algorithms for whole-body MRI-based AC (MRAC): a basic MR image segmentation algorithm and a method based on atlas registration and pattern recognition (ATPR). METHODS: Eleven patients each underwent a whole-body PET/CT study and a separate multibed whole-body MRI study. The MR image segmentation algorithm uses a combination of image thresholds, Dixon fat-water segmentation, and component analysis to detect the lungs. MR images are segmented into 5 tissue classes (not including bone), and each class is assigned a default linear attenuation value. The ATPR algorithm uses a database of previously aligned pairs of MRI/CT image volumes. For each patient, these pairs are registered to the patient MRI volume, and machine-learning techniques are used to predict attenuation values on a continuous scale. MRAC methods are compared via the quantitative analysis of AC PET images using volumes of interest in normal organs and on lesions. We assume the PET/CT values after CT-based AC to be the reference standard. RESULTS: In regions of normal physiologic uptake, the average error of the mean standardized uptake value was 14.1 ± 10.2 and 7.7 ± 8.4 for the segmentation and the ATPR methods, respectively. Lesion-based errors were 7.5 ± 7.9 for the segmentation method and 5.7 ± 4.7 for the ATPR method. CONCLUSION: The MRAC method using ATPR provided better overall PET quantification accuracy than the basic MR image segmentation approach. This better quantification was due to the significantly reduced volume of errors made regarding volumes of interest within or near bones and the slightly reduced volume of errors made regarding areas outside the lungs.

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 Dates: 2011-09
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.2967/jnumed.110.078949
BibTex Citekey: HofmannBMASBPS2011
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Title: Journal of Nuclear Medicine
  Other : J. Nucl. Med.
Source Genre: Journal
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Publ. Info: New York : Society of Nuclear Medicine
Pages: - Volume / Issue: 52 (9) Sequence Number: - Start / End Page: 1392 - 1399 Identifier: ISSN: 0161-5505
CoNE: https://pure.mpg.de/cone/journals/resource/991042725914954