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  Structure-related variable responses of calcium sensitive MRI probes

Mamdedov, I., Logothetis, N., & Angelovski, G. (2011). Structure-related variable responses of calcium sensitive MRI probes. Organic & Biomolecular Chemistry, 9(16), 5816-5824. doi:10.1039/C1OB05463E.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-BB12-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-B576-E
Genre: Journal Article

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Mamdedov, I1, 2, Author              
Logothetis, NK1, 2, Author              
Angelovski, G1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: A new series of Gd3+ complexes based on DO3A (GdL1–GdL4) was synthesized and investigated. They possess side chains with different structures which determine their varying binding properties and response towards endogenous metal ions, measured by changes in the longitudinal relaxivity (r1). GdL4 exhibits the highest selectivity toward Ca2+ in comparison to the other complexes, with up to a 63 increase of the r1. GdL2 and GdL3 also respond to different Ca2+ concentration ranges, however with a lower selectivity since the r1 changes are also observed in the presence of other cations such as Mg2+, Zn2+ or Cu2+. Assessment of the hydration number (q) via luminescence lifetime measurements confirmed that the change in q is responsible for the r1 response for all the complexes.

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 Dates: 2011-07
 Publication Status: Published in print
 Pages: -
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 Rev. Type: -
 Identifiers: URI: http://pubs.rsc.org/en/content/articlepdf/2011/ob/c1ob05463e
DOI: 10.1039/C1OB05463E
BibTex Citekey: MamdedovLA2011
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Title: Organic & Biomolecular Chemistry
  Other : Organic and Biomolecular Chemistry
  Abbreviation : Org. Biomol. Chem.
Source Genre: Journal
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Publ. Info: Cambridge : Royal Society of Chemistry
Pages: - Volume / Issue: 9 (16) Sequence Number: - Start / End Page: 5816 - 5824 Identifier: ISSN: 1477-0520
CoNE: https://pure.mpg.de/cone/journals/resource/954925269322