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  Magnetization exchange with water and T1 relaxation of the downfield resonances in human brain spectra at 3.0 T

MacMillan, E., Chong, D., Dreher, W., Henning, A., Boesch, C., & Kreis, R. (2011). Magnetization exchange with water and T1 relaxation of the downfield resonances in human brain spectra at 3.0 T. Magnetic Resonance in Medicine, 65(5), 1239-1246. doi:10.1002/mrm.22813.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-BBB0-D Version Permalink: http://hdl.handle.net/21.11116/0000-0001-B7E9-A
Genre: Journal Article

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 Creators:
MacMillan, EL, Author
Chong, DGQ, Author
Dreher, W, Author
Henning, A1, Author              
Boesch, C, Author
Kreis, R, Author
Affiliations:
1Institute for Biomedical Engineering, University and ETH Zurich, ou_persistent22              

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 Abstract: The use of water suppression for in vivo proton MR spectroscopy diminishes the signal intensities from resonances that undergo magnetization exchange with water, particularly those downfield of water. To investigate these exchangeable resonances, an inversion transfer experiment was performed using the metabolite cycling technique for non-water-suppressed MR spectroscopy from a large brain voxel in 11 healthy volunteers at 3.0 T. The exchange rates of the most prominent peaks downfield of water were found to range from 0.5 to 8.9 s−1, while the T1 relaxation times in absence of exchange were found to range from 175 to 525 ms. These findings may help toward the assignments of the downfield resonances and a better understanding of the sources of contrast in chemical exchange saturation transfer imaging.

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 Dates: 2011-05
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/mrm.22813
BibTex Citekey: MacMillanCDHBK2011
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 65 (5) Sequence Number: - Start / End Page: 1239 - 1246 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149