Help Privacy Policy Disclaimer
  Advanced SearchBrowse


  The effect of patient positioning aids on PET quantification in PET/MR imaging

Mantlik, F., Hofmann, M., Werner, M., Sauter, A., Kupferschläger, J., Schölkopf, B., et al. (2011). The effect of patient positioning aids on PET quantification in PET/MR imaging. European Journal of Nuclear Medicine and Molecular Imaging, 38(5), 920-929. doi:10.1007/s00259-010-1721-9.

Item is


show Files




Mantlik, F1, 2, Author           
Hofmann, M1, 2, Author           
Werner, MK, Author
Sauter, A, Author
Kupferschläger, J, Author
Schölkopf, B1, 2, Author           
Pichler, BJ, Author
Beyer, T, Author
1Department Empirical Inference, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497795              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              


Free keywords: -
 Abstract: Objectives Clinical PET/MR requires the use of patient positioning aids to immobilize and support patients for the duration of the combined examination. Ancillary immobilization devices contribute to overall attenuation of the PET signal, but are not detected with conventional MR sequences and, hence, are ignored in standard MR-based attenuation correction (MR-AC). We report on the quantitative effect of not accounting for the attenuation of patient positioning aids in combined PET/MR imaging. Methods We used phantom and patient data acquired with positioning aids on a PET/CT scanner (Biograph 16, HI-REZ) to mimic PET/MR imaging conditions. Reference CT-based attenuation maps were generated from measured (original) CT transmission images (origCT-AC). We also created MR-like attenuation maps by following the same conversion procedure of the attenuation values except for the prior delineation and subtraction of the positioning aids from the CT images (modCT-AC). First, a uniform 68Ge cylinder was positioned centrally in the PET/CT scanner and fixed with a vacuum mattress (10 cm thick) and, in a repeat examination, with MR positioning foam pads. Second, 16 patient datasets were selected for subsequent processing. All patients were regionally immobilized with positioning aids: a vacuum mattress for head/neck imaging (nine patients) and a foam mattress for imaging of the lower extremities (seven patients). PET images were reconstructed following CT-based attenuation and scatter correction using the original and modified (MR-like) CT images: PETorigCT-AC and PETmodCT-AC, respectively. PET images following origCT-AC and modCT-AC were compared visually and in terms of mean differences of voxels with a standardized uptake value of at least 1.0. In addition, we report maximum activity concentration in lesions for selected patients. Results In the phantom study employing the vacuum mattress the average voxel activity in PETmodCT-AC was underestimated by 6.4 compared to PETorigCT-AC, with 3.4 of the PET voxels being underestimated by 10 or more. When the MR foam pads were not accounted for during AC, PETmodCT-AC was underestimated by 1.1 on average, with none of the PET voxels being underestimated by 10 or more. Evaluation of the head/neck patient data showed a decrease of 8.4 ([68Ga]DOTATOC) and 7.4 ([18F]FDG) when patient positioning aids were not accounted for during AC, while the corresponding decrease was insignificant for the lower extremities. Conclusion Depending on the size and density of the positioning aids used, a regionally variable underestimation of PET activity following AC is observed when positioning aids are not accounted for. This underestimation may become relevant in combined PET/MR imaging of patients with neuropsychiatric indications, but appears to be of no clinical relevance in imaging the extremities.


 Dates: 2011-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/s00259-010-1721-9
BibTex Citekey: MantlikHWSKSPB2011
 Degree: -



Legal Case


Project information


Source 1

Title: European Journal of Nuclear Medicine and Molecular Imaging
  Other : Eur. J. Nucl. Med. Mol. Imaging
Source Genre: Journal
Publ. Info: Heidelberg, Germany : Springer-Verlag
Pages: - Volume / Issue: 38 (5) Sequence Number: - Start / End Page: 920 - 929 Identifier: ISSN: 1619-7070
CoNE: https://pure.mpg.de/cone/journals/resource/954925519624