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  Measurement of CMRO2 changes by somatosensory stimulation in rat using oxygen-17 at 16.4 T

Wiesner, H., Pohmann, R., Balla, D., Chen, W., Ugurbil, K., & Uludag, K. (2011). Measurement of CMRO2 changes by somatosensory stimulation in rat using oxygen-17 at 16.4 T. Poster presented at 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011), Montréal, Canada.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-BC04-9 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0002-4C27-E
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ISMRM-2011-Wiesner.pdf (Zusammenfassung), 166KB
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 Urheber:
Wiesner, HM1, 2, Autor           
Pohmann, R1, 2, Autor           
Balla, DZ1, 2, Autor           
Chen, W, Autor
Ugurbil, K, Autor
Uludag, K1, 2, Autor           
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Zusammenfassung: We have observed the first directly measured CMRO2 changes in rats by peripheral somatosensory stimulation at an ultrahigh field strength of 16.4 Tesla. The results show that apart from the high sensitivity required also the stability of baseline metabolism is crucial in detecting
small CMRO2 changes evoked by increased neural activity. Lower global baseline metabolism was found when ventilating with a N2O vs. N2 mixture of equal O2 fraction due to the increased anesthetic effect of N2O in agreement with previous work. The direct detection of changes in CMRO2 can also help to investigate the metabolic changes in negative BOLD activations on the ipsilateral hemisphere. Our results are also in accordance with previous results using 17O for CMRO2 measurements from other species at 9.4T.

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 Datum: 2011-05
 Publikationsstatus: Erschienen
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 Identifikatoren: BibTex Citekey: 7091
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Veranstaltung

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Titel: 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011)
Veranstaltungsort: Montréal, Canada
Start-/Enddatum: 2011-05-07 - 2011-05-13

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Titel: 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011)
Genre der Quelle: Konferenzband
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Seiten: - Band / Heft: - Artikelnummer: 5868 Start- / Endseite: 1482 Identifikator: -