English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The effect of a pharmacological ketamine challenge on working memory and brain metabolism

Scheidegger, M., Boeker, H., Seifritz, E., Boesiger, P., Bajbouj, M., Walter, M., et al. (2011). The effect of a pharmacological ketamine challenge on working memory and brain metabolism. Poster presented at 66th Society of Biological Psychiatry Annual Meeting 2011, San Francisco, CA, USA.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-BC0C-A Version Permalink: http://hdl.handle.net/21.11116/0000-0002-4FB3-C
Genre: Poster

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Scheidegger, M, Author
Boeker, H, Author
Seifritz, E, Author
Boesiger, P, Author
Bajbouj, M, Author
Walter, M, Author              
Henning, A1, Author              
Grimm, S, Author
Affiliations:
1ETH and University Zürich, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Background / Purpose: Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties at subanaesthetic doses, thus providing a valuable research tool for the investigation of the neurobiology of mood disorders. Increasing evidence under-scores the role of glutamate dependent neuroplasticity and glutamatergic neurotransmission and metabolism in the patho-physiology of major depressive disorder.Hence, the effects of ketamine on functional brain activity during emotional and cognitive processing have to be further investigated in order to understand its rapid antidepressant properties. This imaging study in 14 healthy subjects aims at probing the neuropharmacological effects of a single intravenous subanaesthetic ketamine infusion on fMRI-BOLD responses during a working memory task using affective stimuli compared to baseline conditions. Main conclusion: Ketamine administration had no effect on working memory performance, accordingly neural activity in the DLPFC did not differ between the baseline and the ketamine session. However, there was a significant ketamine effect on negative BOLD- responses in anterior (pregenual anterior cingulate), but not posterior (posterior cingulate) regions of the default- mode network and thus seems to induce a decoupling of neural activity in anterior and posterior regions of the network.

Details

show
hide
Language(s):
 Dates: 2011-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: BibTex Citekey: ScheideggerBSBBWHG2011
DOI: 10.1016/j.biopsych.2011.03.031
 Degree: -

Event

show
hide
Title: 66th Society of Biological Psychiatry Annual Meeting 2011
Place of Event: San Francisco, CA, USA
Start-/End Date: 2011-05-12 - 2011-05-14

Legal Case

show

Project information

show

Source 1

show
hide
Title: Biological Psychiatry
  Other : Biol. Psychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 69 (9 Supplement) Sequence Number: 547 Start / End Page: 164 Identifier: ISSN: 0006-3223
CoNE: https://pure.mpg.de/cone/journals/resource/954925384111