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  Critical In Vitro Evaluation of Responsive MRI Contrast Agents for Calcium and Zinc

Mishra, A., Logothetis, N., & Parker, D. (2011). Critical In Vitro Evaluation of Responsive MRI Contrast Agents for Calcium and Zinc. Chemistry: A European Journal, 17(5), 1529-1537. doi:10.1002/chem.201001548.

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Mishra, A1, 2, Author           
Logothetis, NK1, 2, Author           
Parker, D, Author
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1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: The synthesis of two gadolinium(III) complexes that exhibit an increase in proton relaxivity in the presence of added Ca2+ or Zn2+ ions is reported. The complexes increase their hydration state from zero to one following metal-ion binding, confirmed by spectral measurements on the corresponding EuIII complexes. At a field of 1.48197;T and 3108197;K, modulation of relaxivity of the order of 30–408201; was observed in mouse serum in each case. The dissociation constants for Ca2+ and Zn2+ binding were sensitive to the presence of added bicarbonate, and were 4508197;956;M (Ca2+) and 2008197;956;M (Zn2+) in serum. Such systems may, therefore, be considered for use as magnetic resonance imaging (MRI) contrast agents to track the restoration of changes in metal-ion concentration in the cerebrospinal fluid of the brain, following neural stimulation.

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 Dates: 2011-02
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/chem.201001548
BibTex Citekey: 7097
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Title: Chemistry: A European Journal
Source Genre: Journal
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Pages: - Volume / Issue: 17 (5) Sequence Number: - Start / End Page: 1529 - 1537 Identifier: -