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  Enhanced neurochemical profile of the rat brain using in vivo 1H NMR spectroscopy at 16.4 T

Hong, S.-T., Balla, D., Shajan, G., Choi, C., Ugurbil, K., & Pohmann, R. (2011). Enhanced neurochemical profile of the rat brain using in vivo 1H NMR spectroscopy at 16.4 T. Magnetic Resonance in Medicine, 65(1), 28-34. doi:10.1002/mrm.22609.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-BCC6-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-BCE0-E
Genre: Journal Article

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Hong, S-T1, 2, Author              
Balla, DZ1, 2, Author              
Shajan, G1, 2, Author              
Choi, C, Author
Ugurbil, K, Author
Pohmann, R1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Single voxel magnetic resonance spectroscopy with ultrashort echo time was implemented at 16.4 T to enhance the neurochemical profile of the rat brain in vivo. A TE of 1.7 msec was achieved by sequence optimization and by using short-duration asymmetric pulses. Macromolecular signal components were parameterized individually and included in the quantitative analysis, replacing the use of a metabolite-nulled spectrum. Because of the high spectral dispersion, several signals close to the water line could be detected, and adjacent peaks could be resolved. All 20 metabolites detected in this study were quantified with Cramér-Rao lower bounds below 20, implying reliable quantification accuracy. The signal of acetate was detected for the first time in rat brain in vivo with Cramér-Rao lower bounds of 16 and a concentration of 0.52 μmol/g. The absolute concentrations of most metabolites showed close agreement with values previously measured using in vivo 1H NMR spectroscopy and in vitro biochemical assay.

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 Dates: 2011-01
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1002/mrm.22609
BibTex Citekey: 6686
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 65 (1) Sequence Number: - Start / End Page: 28 - 34 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149