English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  In Vivo Characterization of a Smart MRI Agent That Displays an Inverse Response to Calcium Concentration

Mamedov, I., Canals, S., Henig, J., Beyerlein, M., Murayama, Y., Mayer, H., et al. (2010). In Vivo Characterization of a Smart MRI Agent That Displays an Inverse Response to Calcium Concentration. ACS Chemical Neuroscience, 1(12), 819-828. doi:10.1021/cn100083a.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-BD20-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-68A1-3
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Mamedov, I1, 2, Author              
Canals, S1, 2, Author              
Henig, J, Author
Beyerlein, M1, 2, Author              
Murayama, Y1, 2, Author              
Mayer, HA, Author
Logothetis, NK1, 2, Author              
Angelovski, G1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: Contrast agents for magnetic resonance imaging (MRI) that exhibit sensitivity toward specific ions or molecules represent a challenging but attractive direction of research. Here a Gd3+ complex linked to an aminobis(methylenephosphonate) group for chelating Ca2+ was synthesized and investigated. The longitudinal relaxivity (r1) of this complex decreases during the relaxometric titration with Ca2+ from 5.76 to 3.57 mMamp;amp;8722;1 samp;amp;8722;1 upon saturation. The r1 is modulated by changes in the hydration number, which was confirmed by determination of the luminescence emission lifetimes of the analogous Eu3+ complex. The initial in vivo characterization of this responsive contrast agent was performed by means of electrophysiology and MRI experiments. The investigated complex is fully biocompatible, having no observable effect on neuronal function after administration into the brain ventricles or parenchyma. Distribution studies demonstrated that the diffusivity of this agent is significantly lower compared with that of gadoliniumamp;amp;8722;diethylenetriaminepentaacetic acid (Gdamp;amp;8722;DTPA).

Details

show
hide
Language(s):
 Dates: 2010-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1021/cn100083a
BibTex Citekey: 6854
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: ACS Chemical Neuroscience
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 1 (12) Sequence Number: - Start / End Page: 819 - 828 Identifier: ISSN: 1948-7193
CoNE: https://pure.mpg.de/cone/journals/resource/1948-7193