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  Using an Infinite Von Mises-Fisher Mixture Model to Cluster Treatment Beam Directions in External Radiation Therapy

Bangert, M., Hennig, P., & Oelfke, U. (2010). Using an Infinite Von Mises-Fisher Mixture Model to Cluster Treatment Beam Directions in External Radiation Therapy. In S. Draghici, T. Khoshgoftaar, V. Palade, W. Pedrycz, M. Wani, & X. Zhu (Eds.), Ninth International Conference on Machine Learning and Applications (ICMLA 2010) (pp. 746-751). Piscataway, NJ, USA: IEEE.

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 Creators:
Bangert, M, Author
Hennig, P1, Author           
Oelfke, U, Author
Affiliations:
1Cavendish Laboratory, Cambridge, United Kingdom, ou_persistent22              

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 Abstract: We present a method for fully automated selection of treatment beam ensembles for external radiation therapy. We reformulate the beam angle selection problem as a clustering problem of locally ideal beam orientations distributed on the unit sphere. For this purpose we construct an infinite mixture of von Mises-Fisher distributions, which is suited in general for density estimation from data on the D-dimensional sphere. Using a nonparametric Dirichlet process prior, our model infers probability distributions over both the number of clusters and their parameter values. We describe an efficient Markov chain Monte Carlo inference algorithm for posterior inference from experimental data in this model. The performance of the suggested beam angle selection framework is illustrated for one intra-cranial, pancreas, and prostate case each. The infinite von Mises-Fisher mixture model (iMFMM) creates between 18 and 32 clusters, depending on the patient anatomy. This suggests to use the iMFMM directly for beam ensemble selection in robotic radio surgery, or to generate low-dimensional input for both subsequent optimization of trajectories for arc therapy and beam ensemble selection for conventional radiation therapy.

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 Dates: 2010-12
 Publication Status: Published in print
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1109/ICMLA.2010.114
BibTex Citekey: BangertHO2010
 Degree: -

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Title: Ninth International Conference on Machine Learning and Applications (ICMLA 2010)
Place of Event: Washington, DC, USA
Start-/End Date: 2010-12-12 - 2010-12-14

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Title: Ninth International Conference on Machine Learning and Applications (ICMLA 2010)
Source Genre: Proceedings
 Creator(s):
Draghici, S, Editor
Khoshgoftaar, TM, Editor
Palade, V, Editor
Pedrycz, W, Editor
Wani, MA, Editor
Zhu, X, Editor
Affiliations:
-
Publ. Info: Piscataway, NJ, USA : IEEE
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 746 - 751 Identifier: ISBN: 978-1-4244-9211-4