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  Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-Å resolution

Armache, J.-P., Jarasch, A., Anger, A., Villa, E., Becker, T., Bhushan, S., et al. (2010). Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-Å resolution. Proceedings of the National Academy of Sciences of the United States of America, 107(46), 19748-19753. doi:10.1073/pnas.1009999107.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-BD5C-0 Version Permalink: https://hdl.handle.net/21.11116/0000-0002-68B2-0
Genre: Journal Article

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http://www.pnas.org/content/pnas/107/46/19748.full.pdf (Publisher version)
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 Creators:
Armache, J-P, Author
Jarasch, A, Author
Anger, AM, Author
Villa, E, Author
Becker, T, Author
Bhushan, S, Author
Jossinet, F, Author
Habeck, M1, 2, Author           
Dindar, G, Author
Franckenberg , S, Author
Marguez, V, Author
Mielke, T, Author
Thomm, M, Author
Berninghausen, O, Author
Beatrix, B, Author
Söding, J, Author
Westhof, E, Author
Wilson, DN, Author
Beckmann, R, Author
Affiliations:
1Department Empirical Inference, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497795              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structures of eukaryotic 80S ribosomes are lacking. Using cryoelectron microscopy and single-particle reconstruction, we have determined the structure of a translating plant (Triticum aestivum) 80S ribosome at 5.5-Å resolution. This map, together with a 6.1-Å map of a Saccharomyces cerevisiae 80S ribosome, has enabled us to model ∼98 of the rRNA. Accurate assignment of the rRNA expansion segments (ES) and variable regions has revealed unique ES–ES and r-protein–ES interactions, providing insight into the structure and evolution of the eukaryotic ribosome.

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 Dates: 2010-11
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1073/pnas.1009999107
BibTex Citekey: ArmacheJAVBBJHDFMMTBBSWWB2011
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : PNAS
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 107 (46) Sequence Number: - Start / End Page: 19748 - 19753 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230