English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Coupling of neural activity and fMRI-BOLD in the motion area MT

Lippert, M., Steudel, T., Ohl, F., Logothetis, N., & Kayser, C. (2010). Coupling of neural activity and fMRI-BOLD in the motion area MT. Magnetic Resonance in Medicine, 28(8), 1087-1094. doi:10.1016/j.mri.2009.12.028.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-BDB8-D Version Permalink: http://hdl.handle.net/21.11116/0000-0002-6A71-8
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Lippert, MT1, 2, Author              
Steudel, T1, 2, Author              
Ohl, F, Author
Logothetis, NK1, 2, Author              
Kayser, C1, 2, 3, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Research Group Physiology of Sensory Integration, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497808              

Content

show
hide
Free keywords: -
 Abstract: The fMRI-BOLD contrast is widely used to study the neural basis of sensory perception and cognition. This signal, however, reflects neural activity only indirectly, and the detailed mechanisms of neurovascular coupling and the neurophysiological correlates of the BOLD signal remain debated. Here we investigate the coupling of BOLD and electrophysiological signals in the motion area MT of the macaque monkey by simultaneously recording both signals. Our results demonstrate that a prominent neuronal response property of area MT, so-called motion opponency, can be used to induce dissociations of BOLD and neuronal firing. During the presentation of a stimulus optimally driving the local neurons, both field potentials [local field potentials (LFPs)] and spiking activity [multi-unit activity (MUA)] correlated with the BOLD signal. When introducing the motion opponency stimulus, however, correlations of MUA with BOLD were much reduced, and LFPs were a much better predictor of the BOLD signal than MUA. In addition, fo r a subset of recording sites we found positive BOLD and LFP responses in the presence of decreases in MUA, regardless of the stimulus used. Together, these results demonstrate that correlations between BOLD and MUA are dependent on the particular site and stimulus paradigm, and foster the notion that the fMRI-BOLD signal reflects local dendrosomatic processing and synaptic activity rather than principal neuron spiking responses.

Details

show
hide
Language(s):
 Dates: 2010-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.mri.2009.12.028
BibTex Citekey: 6385
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Magnetic Resonance in Medicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 28 (8) Sequence Number: - Start / End Page: 1087 - 1094 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149