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  Number and Laminar Distribution of Neurons in a Thalamocortical Projection Column of Rat Vibrissal Cortex

Meyer, H., Wimmer, V., Oberländer, M., de Kock, C., Sakmann, B., & Helmstaedter, M. (2010). Number and Laminar Distribution of Neurons in a Thalamocortical Projection Column of Rat Vibrissal Cortex. Cerebral Cortex, 20(10), 2277-2286. doi:10.1093/cercor/bhq067.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-BDCC-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-6A8F-7
Genre: Journal Article

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 Creators:
Meyer, HS, Author
Wimmer, VC, Author
Oberländer, M1, Author              
de Kock, CPJ, Author
Sakmann, B, Author
Helmstaedter, M, Author
Affiliations:
1Max Planck Institute for Medical Research, Heidelberg, ou_persistent22              

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 Abstract: This is the second article in a series of three studies that investigate the anatomical determinants of thalamocortical (TC) input to excitatory neurons in a cortical column of rat primary somatosensory cortex (S1). Here, we report the number and distribution of NeuN-positive neurons within the C2, D2, and D3 TC projection columns in P27 rat somatosensory barrel cortex based on an exhaustive identification of 89 834 somata in a 1.15 mm3 volume of cortex. A single column contained 19 109 ± 444 neurons (17 560 ± 399 when normalized to a standard-size projection column). Neuron density differences along the vertical column axis delineated “cytoarchitectonic” layers. The resulting neuron numbers per layer in the average column were 63 ± 10 (L1), 2039 ± 524 (L2), 3735 ± 905 (L3), 4447 ± 439 (L4), 1737 ± 251 (L5A), 2235 ± 99 (L5B), 3786 ± 168 (L6A), and 1066 ± 170 (L6B). These data were then used to derive the layer-specific action potential (AP) output of a projection column. The estimates confirmed previous reports suggesting that the ensembles of spiny L4 and thick-tufted pyramidal neurons emit the major fraction of APs of a column. The number of APs evoked in a column by a sensory stimulus (principal whisker deflection) was estimated as 4441 within 100 ms post-stimulus.

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 Dates: 2010-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/cercor/bhq067
BibTex Citekey: MeyerWOdSH2010
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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 20 (10) Sequence Number: - Start / End Page: 2277 - 2286 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440