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  Cellular mechanisms of long-term depression induced by noradrenaline in rat prefrontal neurons prefrontal neurons

Marzo, A., Bai, J., Caboche, J., Vanhoutte, P., & Otani, S. (2010). Cellular mechanisms of long-term depression induced by noradrenaline in rat prefrontal neurons prefrontal neurons. Neuroscience, 169(11), 74-86. doi:10.1016/j.neuroscience.2010.04.046.

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Marzo, A1, Autor           
Bai, J, Autor
Caboche, J, Autor
Vanhoutte, P, Autor
Otani, S, Autor
Affiliations:
1External Organizations, ou_persistent22              

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 Zusammenfassung: Noradrenaline (NA) is released in the prefrontal cortex (PFC) during salient behavioral phases
and thought to modulate PFC-mediated cognitive functions. However, cellular actions of NA
in PFC neurons are still not well understood. In the present study, we investigated long-term
effects of bath-applied NA (12.5 min) on glutamatergic synaptic transmission in rat PFC
pyramidal neurons maintained in vitro. We found that NA concentration-dependently (5 956;M-20 956;M) induces long-term depression (LTD) of layer I-II to layer V pyramidal neuron
glutamatergic synapses. NA acts through alpha1- and alpha2- adrenoceptors, but not beta-adrenoceptors,
to induce LTD. This NA-induced LTD depends on concurrent single synaptic activations of
N-methyl-D-aspartate (NMDA) receptors and requires the activation of protein kinase C and
postsynaptic Extracellular signal-Regulated Kinases (ERK1/2). Western blot analyses showed
that NA (20 956;M for 12.5 min) indeed induces transient increases of ERK1/2 phosphorylation
in PFC neurons, which is dependent at least in part on the activation of NMDA receptors and
alpha1-adrenoceptors. Together, these results demonstrate that NA can lastingly depress
glutamatergic synapses in rat PFC neurons through mechanisms involving alpha-adrenoceptors,
NMDA receptors, and the activation of postsynaptic ERK1/2.

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 Datum: 2010-08
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1016/j.neuroscience.2010.04.046
BibTex Citekey: 6514
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Titel: Neuroscience
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Oxford : Pergamon
Seiten: - Band / Heft: 169 (11) Artikelnummer: - Start- / Endseite: 74 - 86 Identifikator: ISSN: 0306-4522
CoNE: https://pure.mpg.de/cone/journals/resource/954925514498