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  Hybrid PET/MRI of Intracranial Masses: Initial Experiences and Comparison to PET/CT

Boss, A., Bisdas, S., Kolb, A., Hofmann, M., Ernemann, U., Claussen, C., et al. (2010). Hybrid PET/MRI of Intracranial Masses: Initial Experiences and Comparison to PET/CT. Journal of Nuclear Medicine, 51(8), 1198-1205. doi:10.2967/jnumed.110.074773.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-BEA8-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-A4E6-1
Genre: Journal Article

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 Creators:
Boss, A, Author
Bisdas, S, Author
Kolb, A, Author
Hofmann, M1, 2, Author              
Ernemann, U, Author
Claussen, CD, Author
Pfannenberg, C, Author
Pichler, B, Author
Reimold, M, Author
Stegger, L, Author
Affiliations:
1Department Empirical Inference, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497795              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Simultaneous PET and MRI using new hybrid PET/MRI systems promises optimal spatial and temporal coregistration of structural, functional, and molecular image data. In a pilot study of 10 patients with intracranial masses, the feasibility of tumor assessment using a PET/MRI system comprising lutetium oxyorthosilicate scintillators coupled to avalanche photodiodes was evaluated, and quantification accuracy was compared with conventional PET/CT datasets. Methods: All measurements were performed with a hybrid PET/MRI scanner consisting of a conventional 3-T MRI scanner in combination with an inserted MRI-compatible PET system. Attenuation correction of PET/MR images was computed from MRI datasets. Diagnoses at the time of referral were low-grade astrocytoma (n = 2), suspicion of low-grade astrocytoma (n = 1), anaplastic astrocytoma (World Health Organization grade III; n = 1), glioblastoma (n = 2), atypical neurocytoma (n = 1), and meningioma (n = 3). In the glial tumors, 11C-methionine was used for PET; in the meningiomas, 68Ga-DOTATOC was administered. Tumor–to–gray matter and tumor–to–white matter ratios were calculated for gliomas, and tracer uptake of meningiomas was referenced to nasal mucosa. PET/MRI was performed directly after clinically indicated PET/CT examination. Results: In all patients, the PET datasets showed similar diagnostic image quality on the hybrid PET/MRI and the PET/CT studies; however, slight streak artifacts were visible in coronal and sagittal sections when using the higher intrinsic resolution of the PET/MRI insert. Prefiltering of images with a 4-mm gaussian filter at a resolution comparable to that of the PET/CT system virtually eliminated these artifacts. Although acquisition of the PET/MR images started at 30–60 min after PET/CT (20.4-min half-life of 11C) acquisition, the signal-to-noise ratio was good enough, thus underlining the high sensitivity of the PET insert, compared with whole-body PET systems. The computed tumor–to–reference tissue ratios exhibited an excellent accordance between the PET/MRI and PET/CT systems, with a Pearson correlation coefficient of 0.98. Mean paired relative error was 7.9% ± 12.2%. No significant artifacts or distortions were detected in the simultaneously acquired MR images using the PET/MRI scanner. Conclusion: Structural, functional, and molecular imaging in patients with brain tumors is feasible with diagnostic imaging quality using simultaneous hybrid PET/MR image acquisition.

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 Dates: 2010-08
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.2967/jnumed.110.074773
BibTex Citekey: 6400
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Title: Journal of Nuclear Medicine
  Other : J. Nucl. Med.
Source Genre: Journal
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Publ. Info: New York : Society of Nuclear Medicine
Pages: - Volume / Issue: 51 (8) Sequence Number: - Start / End Page: 1198 - 1205 Identifier: ISSN: 0161-5505
CoNE: https://pure.mpg.de/cone/journals/resource/991042725914954