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  Perceptual Decisions Formed by Accumulation of Audiovisual Evidence in Prefrontal Cortex

Noppeney, U., Ostwald, D., & Werner, S. (2010). Perceptual Decisions Formed by Accumulation of Audiovisual Evidence in Prefrontal Cortex. The Journal of Neuroscience, 30(21), 7434-7446. doi:10.1523/JNEUROSCI.0455-10.2010.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C028-D Version Permalink: http://hdl.handle.net/21.11116/0000-0002-4598-5
Genre: Journal Article

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 Creators:
Noppeney, U1, 2, Author              
Ostwald, D2, 3, Author              
Werner, S1, 2, Author              
Affiliations:
1Research Group Cognitive Neuroimaging, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497804              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Department Human Perception, Cognition and Action, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497797              

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 Abstract: To form perceptual decisions in our multisensory environment, the brain needs to integrate sensory information derived from a common source and segregate information emanating from different sources. Combining fMRI and psychophysics in humans, we investigated how the brain accumulates sensory evidence about a visual source in the context of congruent or conflicting auditory information. In a visual selective attention paradigm, subjects (12 females, 7 males) categorized video clips while ignoring concurrent congruent or incongruent soundtracks. Visual and auditory information were reliable or unreliable. Our behavioral data accorded with accumulator models of perceptual decision making, where sensory information is integrated over time until a criterion amount of information is obtained. Behaviorally, subjects exhibited audiovisual incongruency effects that increased with the variance of the visual and the reliability of the interfering auditory input. At the neural level, only the left inferior frontal sulcus (IFS) showed an "audiovisual-accumulator" profile consistent with the observed reaction time pattern. By contrast, responses in the right fusiform were amplified by incongruent auditory input regardless of sensory reliability. Dynamic causal modeling showed that these incongruency effects were mediated via connections from auditory cortex. Further, while the fusiform interacted with IFS in an excitatory recurrent loop that was strengthened for unreliable task-relevant visual input, the IFS did not amplify and even inhibited superior temporal activations for unreliable auditory input. To form decisions that guide behavioral responses, the IFS may accumulate audiovisual evidence by dynamically weighting its connectivity to auditory and visual regions according to sensory reliability and decisional relevance.

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 Dates: 2010-05
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1523/JNEUROSCI.0455-10.2010
BibTex Citekey: 6593
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Title: The Journal of Neuroscience
  Other : The Journal of Neuroscience: the Official Journal of the Society for Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
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Publ. Info: Washington, DC : Society of Neuroscience
Pages: - Volume / Issue: 30 (21) Sequence Number: - Start / End Page: 7434 - 7446 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1