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  Differential neurochemical responses in the rat striatum with isoflurane or ketamine/xylazine anesthesia: In vivo proton MRS study at 16.4 T

Hoi, C.-B., Hong, S.-T., Kim, S.-Y., Woo, D.-C., Choe, B.-Y., Kang, E., et al. (2010). Differential neurochemical responses in the rat striatum with isoflurane or ketamine/xylazine anesthesia: In vivo proton MRS study at 16.4 T. Poster presented at ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden.

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ISMRM-2010-2407.PDF (Any fulltext), 358KB
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Hoi, C-B, Author
Hong, S-T1, 2, Author              
Kim, S-Y, Author
Woo, D-C, Author
Choe, B-Y, Author
Kang, EH, Author
Yim, S-V, Author
Lee, D-W, Author
Pohmann, R1, 2, Author              
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Since the small animal imaging generally requires anesthesia, anesthetic agents can induce unintended effects on animal physiology that may confound the results of imaging studies [1]. The use of isoflurane and ketamine/xylazine anesthesia is popular in imaging studies of laboratory animals. The striatum is the major input station of the basal ganglia system. It is involved in Parkinson's disease, Huntington’s disease, choreas, choreoathetosis and dyskinesias [2]. Recently, 1H-MRS studies of common and severe neuropsychiatric disorders (e.g., obsessive-compulsive disorder, schizophrenia, etc.) have reported abnormal metabolite levels in the striatum (cudate and putamen nuclei) [3]. The purpose of this study was to evaluate alterations in striatum metabolites of rats between anesthetized with isoflurane and with ketamine/xylazine in proton magnetic resonance spectroscopy (1H-MRS), and to investigate the appropriateness of anesthetic agents for 1H-MRS study.

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 Dates: 2010-05
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: HoiHKWCRKYLP2010
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Title: ISMRM-ESMRMB Joint Annual Meeting 2010
Place of Event: Stockholm, Sweden
Start-/End Date: 2010-05-01 - 2010-05-07

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Title: ISMRM-ESMRMB Joint Annual Meeting 2010
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 2407 Start / End Page: - Identifier: -