Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Estimation of CBF Based on the Metabolic H217O Decay Rate in CMRO2 Measurement Using In Vivo 17O MR Approach

Zhu, X.-H., Zhang, Y., Wiesner, H., Ugurbil, K., & Chen, W. (2010). Estimation of CBF Based on the Metabolic H217O Decay Rate in CMRO2 Measurement Using In Vivo 17O MR Approach. In ISMRM-ESMRMB Joint Annual Meeting 2010.

Item is

Externe Referenzen

einblenden:
ausblenden:
Beschreibung:
-
OA-Status:

Urheber

einblenden:
ausblenden:
 Urheber:
Zhu, X-H, Autor
Zhang, Y, Autor
Wiesner, HM1, 2, Autor           
Ugurbil, K, Autor
Chen, W, Autor
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: In vivo 17O MRS imaging (MRSI) approach at high/ultra-high field has been established for non-invasively mapping the cerebral metabolic rate of oxygen in small animals. However imaging of the cerebral blood flow (CBF) using the same 17O MR approach usually requires invasive procedures for introducing the NMR-visible H2-17O as exogenous tracer. In the previous study we have observed that the metabolic H2-17O water generated from a brief 17O2 gas inhalation, which was commonly used for the CMRO2 measurement, had a much slower washout (or decay) rate compared to that of H2-17O tracerm suggesting possible permeability restrictions in the mitochondrial and/or cellular membranes. In the present study, we found that the decay rate of the metabolic H2-17O is still closely related to cerebral perfusion and its change; and a linear relationship between CBF and H2-17O decay rate can be determined experimentally from combined CBF and CMRO2 measurements in rat brain under varied physiological or pathological conditions.

Details

einblenden:
ausblenden:
Sprache(n):
 Datum: 2010-05
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: BibTex Citekey: 6275
 Art des Abschluß: -

Veranstaltung

einblenden:
ausblenden:
Titel: ISMRM-ESMRMB Joint Annual Meeting 2010
Veranstaltungsort: Stockholm, Sweden
Start-/Enddatum: 2010-05-01 - 2010-05-07

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: ISMRM-ESMRMB Joint Annual Meeting 2010
Genre der Quelle: Konferenzband
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: - Artikelnummer: 716 Start- / Endseite: - Identifikator: -