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  Gadoxane: a Novel Degradable Silsesquioxane Based Macromolecular MRI Contrast Agent

Engelmann, J., Henig, J., Gottschalk, S., & Mayer, H. (2010). Gadoxane: a Novel Degradable Silsesquioxane Based Macromolecular MRI Contrast Agent. Poster presented at ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C078-C Version Permalink: http://hdl.handle.net/21.11116/0000-0002-A4F4-1
Genre: Poster

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ISMRM-ESMRMB-2010-Engelmann.pdf (Any fulltext), 135KB
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ISMRM-ESMRMB-2010-Engelmann.pdf
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Engelmann, J1, 2, Author              
Henig, J, Author
Gottschalk, S1, 2, Author              
Mayer, HA, Author
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Silsesquioxane-based macromolecular MRI-contrast agents have recently been reported to have a compact globular structure resulting in significantly higher relaxivities when compared to smaller MRI-probes. The stability of the core under physiological conditions is unknown so far. We therefore studied the stability of Gadoxane, a new silsesquioxane-based contrast agent connected to eight DOTAGA-gadolinium chelates. The silsesquioxane core was almost completely hydrolyzed under physiological conditions while the integrity of the gadolinium chelate was maintained. In conclusion, these probes cannot be considered as stable anymore. However, their degradability might improve their in vivo-applicability due to a faster renal excretion of the smaller fragments.

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 Dates: 2010-05
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: EngelmannHGM2010
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Title: ISMRM-ESMRMB Joint Annual Meeting 2010
Place of Event: Stockholm, Sweden
Start-/End Date: 2010-05-01 - 2010-05-07

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Title: ISMRM-ESMRMB Joint Annual Meeting 2010
Source Genre: Proceedings
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