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  MR contrast agent composed of cholesterol and peptide nucleic acids: Design, synthesis and cellular uptake

Joshi, R., Mishra, R., Pohmann, R., & Engelmann, J. (2010). MR contrast agent composed of cholesterol and peptide nucleic acids: Design, synthesis and cellular uptake. Bioorganic & Medicinal Chemistry Letters, 20(7), 2238-2241. doi:10.1016/j.bmcl.2010.02.019.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C0B6-F Version Permalink: http://hdl.handle.net/21.11116/0000-0002-7710-6
Genre: Journal Article

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 Creators:
Joshi, R1, 2, Author              
Mishra, R1, 2, Author              
Pohmann, R1, 2, Author              
Engelmann, J1, 2, Author              
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: A new mRNA targeting contrast agent consisting of three main functional domains, (i) gadolinium based magnetic resonance reporter part, (ii) antisense peptide nucleic acids targeted to mRNA, and (iii) cholesterol as the delivery vector, was developed and synthesized. The new contrast agent showed efficient cellular uptake and significant contrast enhancement at very low labeling concentrations (0.5 956;M). However, after uptake into cells the agent was located predominantly in endosomes like a similar cell penetrating peptide conjugated probe. Our results indicate that this newly developed contrast agent could be used for the labeling of cells for optical as well as magnetic resonance imaging.

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 Dates: 2010-04
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.bmcl.2010.02.019
BibTex Citekey: 6384
 Degree: -

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Title: Bioorganic & Medicinal Chemistry Letters
  Other : Bioorg. Med. Chem. Lett.
Source Genre: Journal
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Publ. Info: Oxford : Pergamon
Pages: - Volume / Issue: 20 (7) Sequence Number: - Start / End Page: 2238 - 2241 Identifier: ISSN: 0960-894X
CoNE: https://pure.mpg.de/cone/journals/resource/954925579103