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  A toolbox for predicting G-quadruplex formation and stability

Wong, H., Stegle, O., Rodgers, S., & Huppert, J. (2010). A toolbox for predicting G-quadruplex formation and stability. Journal of Nucleic Acids, 2010: 564946, pp. 1-6. doi:10.4061/2010/564946.

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Wong, HM, Author
Stegle, O1, 2, Author           
Rodgers, S, Author
Huppert, JL, Author
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1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Former Research Group Machine Learning and Computational Biology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528696              

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 Abstract: G-quadruplexes are four stranded nucleic acid structures formed around a core of guanines, arranged in squares with mutual hydrogen bonding. Many of these structures are highly thermally stable, especially in the presence of monovalent cations, such as those found under physiological conditions. Understanding of their physiological roles is expanding rapidly, and they have been implicated in regulating gene transcription and translation among other functions. We have built a community-focused website to act as a repository for the information that is now being developed. At its core, this site has a detailed database (QuadDB) of predicted G-quadruplexes in the human and other genomes, together with the predictive algorithm used to identify them. We also provide a QuadPredict server, which predicts thermal stability and acts as a repository for experimental data from all researchers. There are also a number of other data sources with computational predictions. We anticipate that the wide availability of this information will be of use both to researchers already active in this exciting field and to those who wish to investigate a particular gene hypothesis.

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 Dates: 2010-03
 Publication Status: Published in print
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 Identifiers: DOI: 10.4061/2010/564946
BibTex Citekey: 6531
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Title: Journal of Nucleic Acids
Source Genre: Journal
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Pages: - Volume / Issue: 2010 Sequence Number: 564946 Start / End Page: 1 - 6 Identifier: -