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  Relationship Between Coronary Microvascular Dysfunction and Cardiac Energetics Impairment in Type 1 Diabetes Mellitus

Nallur Shivu, G., Phan, T., Abozguia, K., Ahmed, I., Wagenmakers, A., Henning, A., et al. (2010). Relationship Between Coronary Microvascular Dysfunction and Cardiac Energetics Impairment in Type 1 Diabetes Mellitus. Circulation, 121(10), 1209-1215. doi:10.1161/​CIRCULATIONAHA.109.873273.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C0FA-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-773F-3
Genre: Journal Article

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 Creators:
Nallur Shivu, G, Author
Phan, TT, Author
Abozguia, K, Author
Ahmed, I, Author
Wagenmakers, A, Author
Henning, Anke1, Author              
Narendran, P, Author
Stevens, M, Author
Frenneaux, M, Author
Affiliations:
1Institute for Biomedical Engineering, Swiss Federal Institute of Technology (ETH Zurich) and University of Zurich, ou_persistent22              

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 Abstract: Background— Asymptomatic subjects with diabetes mellitus have an impaired cardiac energetics status that may play a significant role in the development of heart failure. In the present study, we assessed the role of microvascular dysfunction in the development of impaired cardiac energetics in subjects with type 1 diabetes mellitus. Methods and Results— Twenty-five asymptomatic subjects with type 1 diabetes mellitus (mean age ±1 SD 33±8 years) and 26 age-, sex-, and body mass index–matched healthy control subjects (32±8 years old) were recruited into the study. The type 1 diabetes mellitus subjects were divided into 2 age-matched groups (newly diagnosed [<5 years] and longer-duration [>10 years] diabetes) to assess the impact of microvascular disease. All subjects had an echocardiogram and an exercise ECG performed, followed by magnetic resonance spectroscopy and stress magnetic resonance imaging. Compared with healthy control subjects, the phosphocreatine/γ-ATP ratio was reduced significantly both in subjects with longer-term (2.1±0.5 versus 1.5±0.4, P<0.000) and newly diagnosed (2.1±0.5 versus 1.6±0.2, P<0.000) diabetes. The phosphocreatine/γ-ATP ratio was similar in newly diagnosed diabetes subjects and those with longer-term disease (1.6±0.2 versus 1.5±0.4, P=0.32). The mean myocardial perfusion reserve index in the longer-term type 1 diabetes mellitus subjects was significantly lower than in healthy control subjects (1.7±0.6 versus 2.3±0.4, P=0.005). On univariate analysis, there was no significant correlation of phosphocreatine/γ-ATP ratio with myocardial perfusion reserve index (r=0.21, P=0.26). Conclusions— We demonstrate that young subjects with uncomplicated type 1 diabetes mellitus have impaired myocardial energetics irrespective of the duration of diabetes and that the impaired cardiac energetics status is independent of coronary microvascular function. We postulate that impairment of cardiac energetics in these subjects primarily results from metabolic dysfunction rather than microvascular impairment.

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 Dates: 2010-03
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1161/​CIRCULATIONAHA.109.873273
BibTex Citekey: NallurShivuPAAWHNSF2010
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Title: Circulation
Source Genre: Journal
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Publ. Info: Dallas, Tex., etc. : American Heart Association, etc.
Pages: - Volume / Issue: 121 (10) Sequence Number: - Start / End Page: 1209 - 1215 Identifier: ISSN: 0009-7322
CoNE: https://pure.mpg.de/cone/journals/resource/954925390275