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  31P magnetic resonance spectroscopy to measure in vivo cardiac energetics in normal myocardium and hypertrophic cardiomyopathy: Experiences at 3 T

Nallur Shivu, G., Abozguia, K., Phan, T., Ahmed, I., Henning, A., & Frenneaux, M. (2010). 31P magnetic resonance spectroscopy to measure in vivo cardiac energetics in normal myocardium and hypertrophic cardiomyopathy: Experiences at 3 T. European Journal of Radiology, 73(2), 255-259. doi:10.1016/j.ejrad.2008.10.018.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C120-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-7746-A
Genre: Journal Article

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Nallur Shivu, G, Author
Abozguia, K, Author
Phan, TT, Author
Ahmed, I, Author
Henning, Anke1, Author              
Frenneaux, M, Author
Affiliations:
1Institute for Biomedical Engineering, University and ETH Zurich, ou_persistent22              

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 Abstract: Background 31P magnetic resonance spectroscopy (MRS) allows measurement of in vivo high-energy phosphate kinetics in the myocardium. While traditionally 31P cardiac spectroscopy is performed at 1.5 T, cardiac MRS at higher field strength can theoretically increase signal to noise ratio (SNR) and spectral resolution therefore improving sensitivity and specificity of the cardiac spectra. The reproducibility and feasibility of performing cardiac spectroscopy at 3 T is presented here in this study in healthy volunteers and patients with hypertrophic cardiomyopathy. Methods Cardiac spectroscopy was performed using a Phillips 3T Achieva scanner in 37 healthy volunteers and 26 patients with hypertrophic cardiomyopathy (HCM) to test the feasibility of the protocol. To test the reproducibility a single volunteer was scanned eight times on separate occasions. A single voxel 31P MRS was performed using Image Selected In vivo Spectroscopy (ISIS) volume localization. Results The mean phosphocreatine/adenosine triphosphate (PCr/ATP) ratio of the eight measurements performed on one individual was 2.11 ± 0.25. Bland Altman plots showed a variance of 12 in the measurement of PCr/ATP ratios. The PCr/ATP ratio was significantly reduced in HCM patients compared to controls, 1.42 ± 0.51 and 2.11 ± 0.57, respectively, P < 0.0001. (All results are expressed as mean ± standard deviation). Conclusions Here we demonstrate that cardiac 31P MRS at 3 T is a reliable method of measuring in vivo high-energy phosphate kinetics in the myocardium for clinical studies and diagnostics. Based on our data an impairment of cardiac energetic state in patients with hypertrophic cardiomyopathy is indisputable.

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 Dates: 2010-02
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: DOI: 10.1016/j.ejrad.2008.10.018
BibTex Citekey: NallurShivuAPAHF2010
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Title: European Journal of Radiology
  Other : Eur. J. Radiol.
Source Genre: Journal
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Publ. Info: Stuttgart : Elsevier
Pages: - Volume / Issue: 73 (2) Sequence Number: - Start / End Page: 255 - 259 Identifier: ISSN: 0720-048X
CoNE: https://pure.mpg.de/cone/journals/resource/954925532999