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  To dip or not to dip: Reconciling optical imaging and fMRI data

Uludag, K. (2010). To dip or not to dip: Reconciling optical imaging and fMRI data. Proceedings of the National Academy of Sciences of the United States of America, 107(6), E23. doi:10.1073/pnas.0914194107.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C146-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-776A-2
Genre: Journal Article

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http://www.pnas.org/content/107/6/E23.full.pdf (Publisher version)
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Uludag, K1, 2, Author              
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Several optical studies have reported a brief initial increase of deoxyhemoglobin (1), which is consistent with an initial dip observed in the functional MRI (fMRI) signal, evoked by local neuronal activity. This effect is small and not always present (2), but it has stirred great interest because it may reflect a rapid increase of oxidative metabolism before increases in blood flow and, thus, may have a narrower spatial spread than the main positive hemodynamic response. In a recent elegant and comprehensive study, Sirotin et al. (3) investigated the spatiotemporal specificity of intrinsic optical imaging signals at different wavelengths and for different chromophores.

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 Dates: 2010-02
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1073/pnas.0914194107
BibTex Citekey: 6316
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : PNAS
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 107 (6) Sequence Number: - Start / End Page: E23 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230