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  Comparison of pulsed arterial spin labeling encoding schemes and absolute perfusion quantification

Cavusoglu, M., Pfeuffer, J., Ugurbil, K., & Uludag, K. (2009). Comparison of pulsed arterial spin labeling encoding schemes and absolute perfusion quantification. Magnetic Resonance Imaging, 27(8), 1039-1045. doi:10.1016/j.mri.2009.04.002.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C248-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-BB3F-6
Genre: Journal Article

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Cavusoglu, M1, 2, Author              
Pfeuffer, J, Author              
Ugurbil, K, Author
Uludag, K1, 2, Author              
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Arterial spin labeling (ASL) using magnetic resonance imaging (MRI) is a powerful noninvasive technique to investigate the physiological status of brain tissue by measuring cerebral blood flow (CBF). ASL assesses the inflow of magnetically labeled arterial blood into an imaging voxel. In the last 2 decades, various ASL sequences have been proposed which differ in their ease of implementation and their sensitivity to artifacts. In addition, several quantification methods have been developed to determine the absolute value of CBF from ASL magnetization difference images. In this study, we evaluated three pulsed ASL sequences and three absolute quantification schemes. It was found that FAIR-QUIPSSII implementation of ASL yields 10–20 higher signal-to-noise ratio (SNR) and 18 higher CBF as compared with PICORE-Q2TIPS (with FOCI pulses) and PICORE-QUIPSSII (with BASSI pulses). In addition, quantification schemes employed can give rise to up to a 35 difference in CBF values. We conclude that, although all quant itative ASL sequences and CBF calibration methods should in principle result in the similar CBF values and image quality, substantial differences in CBF values and SNR were found. Thus, comparing studies using different ASL sequences and analysis algorithms is likely to result in erroneous intra- and intergroup differences. Therefore, (i) the same quantification schemes should consistently be used, and (ii) quantification using local tissue proton density should yield the most accurate CBF values because, although still requiring definitive demonstration in future studies, the proton density of blood is assumed to be very similar to the value of gray matter.

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 Dates: 2009-10
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1016/j.mri.2009.04.002
BibTex Citekey: 5689
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Title: Magnetic Resonance Imaging
Source Genre: Journal
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Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 27 (8) Sequence Number: - Start / End Page: 1039 - 1045 Identifier: ISSN: 0730-725X
CoNE: https://pure.mpg.de/cone/journals/resource/954925533026