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Abstract:
The maintenance of a gradient of potassium and sodium ions across the cell membranes is essential for the physiological function of the mammal organism. The measurement of the spatial distribution of pathologically changing ion concentrations of 23Na and 39K offers a very promising approach in clinical diagnostics. A lot of imaging and spectroscopy studies of 23Na exist already, as well as several spectroscopy studies and one post mortem imaging study for 39K. For MR imaging of both elements and the acquisition of anatomical proton images in the same experiment without moving the subject or the RF coil a triple-resonant RF coil setup for the rat head at 9.4T was developed. In vivo images of 39K and 23Na in the rat brain were acquired as well as anatomical proton images in the same scanning session.
