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  Vascular graph model to simulate the cerebral blood flow in realistic vascular networks

Reichold, J., Stampanoni, M., Keller, A., Buck, A., Jenny, P., & Weber, B. (2009). Vascular graph model to simulate the cerebral blood flow in realistic vascular networks. Journal of Cerebral Blood Flow and Metabolism, 29(8), 1429-1443. doi:10.1038/jcbfm.2009.58.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C377-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-BE55-9
Genre: Journal Article

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 Creators:
Reichold, J, Author              
Stampanoni, M, Author
Keller, AL1, 2, Author              
Buck, A, Author
Jenny, P, Author
Weber, B, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: At its most fundamental level, cerebral blood flow (CBF) may be modeled as fluid flow driven through a network of resistors by pressure gradients. The composition of the blood as well as the cross-sectional area and length of a vessel are the major determinants of its resistance to flow. Here, we introduce a vascular graph modeling framework based on these principles that can compute blood pressure, flow and scalar transport in realistic vascular networks. By embedding the network in a computational grid representative of brain tissue, the interaction between the two compartments can be captured in a truly three-dimensional manner and may be applied, among others, to simulate oxygen extraction from the vessels. Moreover, we have devised an upscaling algorithm that significantly reduces the computational expense and eliminates the need for detailed knowledge on the topology of the capillary bed. The vascular graph framework has been applied to investigate the effect of local vascular dilation and occlusion on the flow in the surrounding network.

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 Dates: 2009-08
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/jcbfm.2009.58
BibTex Citekey: 6168
 Degree: -

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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
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Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 29 (8) Sequence Number: - Start / End Page: 1429 - 1443 Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202