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  Efficient Intracellular Delivery of an MR Imaging Probe by a Novel Cell Penetrating Peptide

Engelmann, J., Jha, D., Mishra, R., Wiesmüller, K.-H., & Ugurbil, K. (2009). Efficient Intracellular Delivery of an MR Imaging Probe by a Novel Cell Penetrating Peptide. Poster presented at 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2009), Honolulu, HI, USA.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C55F-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1593-F
Genre: Poster

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 Creators:
Engelmann, J1, 2, Author              
Jha, D1, 2, Author              
Mishra, R1, 2, Author              
Wiesmüller, K-H, Author
Ugurbil, K, Author
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: A novel cell penetrating peptide (CyLoP-1) was obtained by structure activity relationship studies. It exhibited efficient transport across the cell membrane and distribution in the entire cytosol as well. These distinctive properties were only slightly influenced by the coupling of Gd-DOTA. This conjugate was slightly less internalized into 3T3 fibroblasts, but the cellular distribution was retained. MR studies on labeled cells revealed an exceptional high contrast enhancement in T1-weighted images. These results demonstrate its potential to be used for efficient transmembrane delivery of imaging agents and as vector for probes specifically targeted to cytosolic constituent.

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 Dates: 2009-04
 Publication Status: Published online
 Pages: -
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 Identifiers: BibTex Citekey: 6261
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Title: 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2009)
Place of Event: Honolulu, HI, USA
Start-/End Date: 2009-04-18 - 2009-04-24

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Title: 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2009)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 3123 Start / End Page: - Identifier: -