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  Liver tissue repair in a mouse model of toxicant-induced liver inury is associated with increased hepatic energy metabolism

Gottschalk, S., Leibfritz, D., Zwingmann, C., & Bilodeau, M. (2009). Liver tissue repair in a mouse model of toxicant-induced liver inury is associated with increased hepatic energy metabolism. In 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2009).

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C565-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-15E5-3
Genre: Meeting Abstract

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Gottschalk, S1, Author              
Leibfritz, D, Author
Zwingmann, C, Author
Bilodeau, M, Author
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1External Organizations, ou_persistent22              

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 Abstract: Due to its ability regenerate, the liver is an ideal model for studying tissue repair mechanisms. Only little is known about the repair-associated changes in cellular metabolic pathways. Energy-intensive repair processes should be reflected in alterations in energy metabolism. An in vivo liver-injury model was used to generate an onset of liver tissue-repair. We assessed the extent of liver-injury and NMR-spectroscopy was used to characterize changes in energy metabolism and metabolites. Our results showed that induction of liver-regeneration was consistent with an up-regulation of the cells overall energy metabolism and a higher demand for TCA-cycle intermediates (eg. for amino-acids synthesis).

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 Dates: 2009-04
 Publication Status: Published online
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 Identifiers: BibTex Citekey: GottschalkLZB2009
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Title: 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2009)
Place of Event: Honolulu, HI, USA
Start-/End Date: 2009-04-18 - 2009-04-24

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Title: 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2009)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 530 Start / End Page: - Identifier: -