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  Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-based Propylphosphonates

Mamedov, I., Táborský, P., Lubal, P., Laurent, S., Elst, L., Logothetis, N., et al. (2009). Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-based Propylphosphonates. Poster presented at Annual Workshop CMST COST Action D38: Metal-Based Systems for Molecular Imaging Applications, Tübingen, Germany.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C573-C Version Permalink: http://hdl.handle.net/21.11116/0000-0002-B430-C
Genre: Poster

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CMST-COST-Action-D38-2009-P33.pdf (Abstract), 38KB
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CMST-COST-Action-D38-2009-P33.pdf
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Mamedov, I1, 2, Author              
Táborský, P, Author
Lubal, P, Author
Laurent, S, Author
Elst, LV, Author
Logothetis, NK1, 2, Author              
Angelovski, G1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Development of the responsive probes is one of the most exciting topics in the contrast agent research. Design of the pH sensitive probes, for example, can be an important issue in the early cancer diagnostic and formation of pH maps.[1] This can be reached by introduction of different functional groups such as phosphonates at the fourth nitrogen of the DO3A molecule. [2] Two DO3A-based ligands and their Gd3+ and Eu3+ complexes containing ethyl-protected and unprotected propylphosphonates in the side chain were investigated. Proton relaxometric in vitro studies at 20 MHz and 60 MHz and 37 °C of the Gd3+ complex containing free acid exhibited relative changes of up to 56 in r1 relaxivity when the pH of the medium was changed from 4 to 7. This change is explained by the increase in the number of coordinated water molecules from 1 to 2. Temperature dependent relaxivity and NMRD profiles of Gd3+ complexes showed a slightly increased rotational correlation time, which is characteristic of phosphonate-containing compounds. Thermodynamic and kinetic studies of the Gd3+ and Eu3+ complexes were performed by means of potentiometry and luminescence spectroscopy. The results indicate that the thermodynamic stability and kinetic inertness of these complexes are sufficient for their in vivo application.

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 Dates: 2009-04
 Publication Status: Published online
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 Identifiers: BibTex Citekey: 6157
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Title: Annual Workshop CMST COST Action D38: Metal-Based Systems for Molecular Imaging Applications
Place of Event: Tübingen, Germany
Start-/End Date: 2009-04-25 - 2009-04-27

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Title: Annual Workshop CMST COST Action D38: Metal-Based Systems for Molecular Imaging Applications
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: P33 Start / End Page: 71 Identifier: -