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  Background dopamine concentration dependently facilitates long-term potentiation in rat prefrontal cortex through postsynaptic activation of extracellular signal-regulated kinases.

Kolomiets, B., Marzo, A., Caboche, J., Vanhoutte, P., & Otani, S. (2009). Background dopamine concentration dependently facilitates long-term potentiation in rat prefrontal cortex through postsynaptic activation of extracellular signal-regulated kinases. Cerebral Cortex, 19(11), 2708-2718. doi:10.1093/cercor/bhp047.

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Kolomiets, B, Author
Marzo, A1, Author              
Caboche, J, Author
Vanhoutte, P, Author
Otani, S, Author
Affiliations:
1External, Max Planck Institute for the History of Science, Max Planck Society, Boltzmannstraße 22, 14195 Berlin, DE, ou_2301692              

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 Abstract: Altered levels of tonic/background dopamine in prefrontal cortex (PFC) may underlie modifications of executive cognitive function. We showed previously in rat PFC slices that exogenously supplied background dopamine facilitates induction of long-term potentiation (LTP), a possible cellular substrate for the long-term component of executive cognitive function. In the present study, we characterized cellular and molecular mechanisms underlying this modulatory dopamine effect. We show first that the LTP-facilitating effect of tonic/background dopamine follows an inverted-U shape concentration curve and that the effective level of background dopamine slowly activates postsynaptic extracellular signal-regulated kinases (ERKs) to facilitate LTP. Furthermore, we show the evidence that LTP-inducing high-frequency stimulation evokes endogenous release of dopamine in PFC slices. This fast dopamine serves as a trigger for LTP in the presence of the background dopamine. In its absence, the endogenous dopamine triggered, instead, long-term depression. These results indicate that appropriate levels of tonic/background dopamine serve to activate critical molecular factors in PFC neurons and thereby facilitate induction of synaptic potentiation.

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 Dates: 2009-03
 Publication Status: Published in print
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 Identifiers: DOI: 10.1093/cercor/bhp047
BibTex Citekey: 6306
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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 19 (11) Sequence Number: - Start / End Page: 2708 - 2718 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440