Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Automatic detection of preclinical neurodegeneration: Presymptomatic Huntington disease

Klöppel, S., Chu, C., Tan, G., Draganski, B., Johnson, H., Paulsen, J., et al. (2009). Automatic detection of preclinical neurodegeneration: Presymptomatic Huntington disease. Neurology, 72(5), 426-431. doi:10.1212/01.wnl.0000341768.28646.b6.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:
ausblenden:
externe Referenz:
http://n.neurology.org/content/72/5/426 (Verlagsversion)
Beschreibung:
-
OA-Status:
Keine Angabe

Urheber

einblenden:
ausblenden:
 Urheber:
Klöppel, S, Autor
Chu, C, Autor
Tan, GC, Autor
Draganski, B, Autor
Johnson, H, Autor
Paulsen, JS, Autor
Kienzle, W1, Autor           
Tabrizi , SJ, Autor
Ashburner, J, Autor
Frackowiak, RSJ, Autor
Affiliations:
1Department Empirical Inference, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497795              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Background: Treatment of neurodegenerative diseases is likely to be most beneficial in the very early, possibly preclinical stages of degeneration. We explored the usefulness of fully automatic structural MRI classification methods for detecting subtle degenerative change. The availability of a definitive genetic test for Huntington disease (HD) provides an excellent metric for judging the performance of such methods in gene mutation carriers who are free of symptoms.
Methods: Using the gray matter segment of MRI scans, this study explored the usefulness of a multivariate support vector machine to automatically identify presymptomatic HD gene mutation carriers (PSCs) in the absence of any a priori information. A multicenter data set of 96 PSCs and 95 age- and sex-matched controls was studied. The PSC group was subclassified into three groups based on time from predicted clinical onset, an estimate that is a function of DNA mutation size and age.
Results: Subjects with at least a 33 chance of developing unequivocal signs of HD in 5 years were correctly assigned to the PSC group 69 of the time. Accuracy improved to 83 when regions affected by the disease were selected a priori for analysis. Performance was at chance when the probability of developing symptoms in 5 years was less than 10.
Conclusions: Presymptomatic Huntington disease gene mutation carriers close to estimated diagnostic onset were successfully separated from controls on the basis of single anatomic scans, without additional a priori information. Prior information is required to allow separation when degenerative changes are either subtle or variable.

Details

einblenden:
ausblenden:
Sprache(n):
 Datum: 2009-02
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: BibTex Citekey: 5891
DOI: 10.1212/01.wnl.0000341768.28646.b6
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Neurology
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Cleveland, Ohio [etc.] : Advanstar Communications [etc.]
Seiten: - Band / Heft: 72 (5) Artikelnummer: - Start- / Endseite: 426 - 431 Identifikator: ISSN: 0028-3878
CoNE: https://pure.mpg.de/cone/journals/resource/954925246073