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  New coil positioning method for interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) and its validation in a motor cortex study

Moisa, M., Pohmann, R., Ewald, L., & Thielscher, A. (2009). New coil positioning method for interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) and its validation in a motor cortex study. Journal of Magnetic Resonance Imaging, 29(1), 189-197. doi:10.1002/jmri.21611.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C5E7-A Version Permalink: http://hdl.handle.net/21.11116/0000-0002-CA41-1
Genre: Journal Article

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 Creators:
Moisa, M1, 2, Author              
Pohmann, R1, 2, Author              
Ewald, L, Author
Thielscher, A1, 2, Author              
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Purpose To develop and test a novel method for the coil placement in interleaved Transcranial Magnetic Stimulation(TMS)/fMRI studies. Materials and Methods Initially, a desired TMS coil position at the subject’s head is recorded using a neuronavigation system. Subsequently, a custom-made holding device is used for coil placement inside the MR scanner. The parameters of the device corresponding to the prerecorded position are automatically determined from a fast structural image acquired directly before the experiment. The spatial accuracy of our method was verified on a phantom. Finally, in a study on 5 subjects, the coil was placed above the cortical representation of a hand muscle in M1 and the BOLD responses to short rTMS trains were assessed using EPI recordings. Results The spatial accuracy of our method is in the range of 2.9±1.3(SD) mm. Motor cortex stimulation resulted in robust BOLD activations in motor- and auditory-related brain areas, with the activation in M1 being localized in the hand knob. Conclusion We present a user-friendly method for TMS coil positioning in the MR scanner that exhibits good spatial accuracy and speeds up the setup of the experiment. The motor-cortex study proves the viability of the approach and validates our interleaved TMS/fMRI setup.

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 Dates: 2009-01
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1002/jmri.21611
BibTex Citekey: 5496
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Title: Journal of Magnetic Resonance Imaging
Source Genre: Journal
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Publ. Info: Chicago, IL : Society for Magnetic Resonance Imaging
Pages: - Volume / Issue: 29 (1) Sequence Number: - Start / End Page: 189 - 197 Identifier: ISSN: 1053-1807
CoNE: https://pure.mpg.de/cone/journals/resource/954925594512