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  The Influence of Moderate Hypercapnia on Neural Activity in the Anesthetized Nonhuman Primate

Zappe, A.-C., Uludag, K., Oeltermann, A., Ugurbil, K., & Logothetis, N. (2008). The Influence of Moderate Hypercapnia on Neural Activity in the Anesthetized Nonhuman Primate. Cerebral Cortex, 18(11), 2666-2673. doi:10.1093/cercor/bhn023.

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Zappe, A-C1, 2, Author           
Uludag, K2, 3, Author           
Oeltermann, A2, 3, Author           
Ugurbil, K, Author
Logothetis, NK1, 2, Author           
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              

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 Abstract: Hypercapnia is often used as vasodilatory challenge in clinical applications and
basic research. In functional magnetic resonance imaging (fMRI), elevated CO2
is applied to derive stimulus-induced changes in the cerebral rate of oxygen
consumption (CMRO2) by measuring cerebral blood flow (CBF) and bloodoxygenation-
level-dependent (BOLD) signal. Such methods, however, assume
that hypercapnia has no direct effect on CMRO2. In this study, we used
combined intracortical recordings and fMRI in the visual cortex of anesthetized
macaque monkeys to show that spontaneous neuronal activity is in fact
significantly reduced by moderate hypercapnia. As expected, measurement of
cerebral blood volume using an exogenous contrast agent and of BOLD signal
showed that both are increased during hypercapnia. In contrast to this,
spontaneous fluctuations of local field potentials in the beta and gamma
frequency range as well as multi-unit activity are reduced by ~15 during
inhalation of 6 CO2 (pCO2 = 56 mmHg). A strong tendency toward a reduction
of neuronal activity was also found at CO2 inhalation of 3 (pCO2 = 45 mmHg).
This suggests that CMRO2 might be reduced during hypercapnia and caution
must be exercised when hypercapnia is applied to calibrate the BOLD signal.

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 Dates: 2008-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/cercor/bhn023
BibTex Citekey: 4956
 Degree: -

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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 18 (11) Sequence Number: - Start / End Page: 2666 - 2673 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440