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  Impairment of learning and memory in TAG-1 deficient mice associated with shorter CNS internodes and disrupted juxtaparanodes.

Savvaki, M., Panagiotaropoulos, T., Stamatakis, A., Sargiannidou, I., Karatzioula, P., Watanabe, K., et al. (2008). Impairment of learning and memory in TAG-1 deficient mice associated with shorter CNS internodes and disrupted juxtaparanodes. Molecular and Cellular Neuroscience, 39(3), 478-490. doi:10.1016/j.mcn.2008.07.025.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C6A3-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-2CB5-0
Genre: Journal Article

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Savvaki, M, Author
Panagiotaropoulos, T1, Author              
Stamatakis, A, Author
Sargiannidou, I, Author
Karatzioula, P, Author
Watanabe, K, Author
Stylianopoulou, F, Author
Karagogeos, D, Author
Kleopa, KA, Author
Affiliations:
1External Organizations, ou_persistent22              

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 Abstract: The cell adhesion molecule TAG-1 is expressed by neurons and glial cells and plays a role in axon outgrowth, migration and fasciculation during development. TAG-1 is also required for the clustering of Kv1.1/1.2 potassium channels and Caspr2 at the juxtaparanodes of myelinated fibers. Behavioral examination of TAG-1 deficient mice (Tag-1amp;8722;/amp;8722;) showed cognitive impairments in the Morris water maze and novel object recognition tests, reduced spontaneous motor activity, abnormal gait coordination and increased response latency to noxious stimulation. Investigation at the molecular level revealed impaired juxtaparanodal clustering of Caspr2 and Kv1.1/1.2 in the hippocampus, entorhinal cortex, cerebellum and olfactory bulb, with diffusion into the internode. Caspr2 and Kv1.1 levels were reduced in the cerebellum and olfactory bulb. Moreover, Tag-1amp;8722;/amp;8722; mice had shorter internodes in the cerebral and cere bellar white mat ter. The detected molecular alterations may account for the behavioural deficits and hyperexcitability in these animals.

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 Dates: 2008-10
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.mcn.2008.07.025
BibTex Citekey: 5449
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Title: Molecular and Cellular Neuroscience
Source Genre: Journal
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Publ. Info: Orlando, Fla. : Academic Press
Pages: - Volume / Issue: 39 (3) Sequence Number: - Start / End Page: 478 - 490 Identifier: ISSN: 1044-7431
CoNE: https://pure.mpg.de/cone/journals/resource/954922650153