English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Mass spectrometry-based neurochemical analysis: perspectives for primate research

Zhang, X., Rauch, A., Xiao, H., Rainer, G., & Logothetis, N. (2008). Mass spectrometry-based neurochemical analysis: perspectives for primate research. Expert Review of Proteomics, 5(5), 641-652. doi:10.1586/14789450.5.5.641.

Item is

Files

show Files

Locators

show
hide
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Zhang, X1, 2, Author           
Rauch, A1, 2, Author           
Xiao , H, Author
Rainer, G1, 2, Author           
Logothetis, NK1, 2, Author           
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: The analysis of neurochemicals from the brain represents a challenge for current analytical techniques due to a variety of factors, such as compositional complexity, limited amounts of sample and endogenous inferences. Advances in mass spectrometry (MS) provide great opportunities for the sensitive measurement of neurochemicals, offering benefits including simple sample preparation, broad capability for analysis of diverse compounds and rich structural information of analytes. Until recently, however, limited numbers of studies have reported on the analysis of small molecular neurochemicals, such as classical neurotransmitters, in part due to the difficulties in separation of polar molecules by using current chromatography techniques with MS-compatible conditions. By contrast, MS has become an indispensable tool for neuropeptide analysis , offering tremendous potential in the discovery of novel signaling peptides and biomarkers. This review covers recent advances in MS-based neurochemical analysis , including a comparison with related detection techniques, chromatographic separation and neuropeptide discovery. Issues relating to in vivo sample collection and sample preparation are discussed. To provide a wider view of the capability of MS in basic neuroscience and clinical research, we discuss MS-based neurochemical analysis conducted in different animal models and humans. We specifically highlight perspectives for the use of MS for brain functional studies and drug discovery in nonhuman primates.

Details

show
hide
Language(s):
 Dates: 2008-10
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1586/14789450.5.5.641
BibTex Citekey: 5591
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Expert Review of Proteomics
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Future Drugs Ltd.
Pages: - Volume / Issue: 5 (5) Sequence Number: - Start / End Page: 641 - 652 Identifier: ISSN: 1478-9450
CoNE: https://pure.mpg.de/cone/journals/resource/111087325416002