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  Direct measurement of oxygen extraction with fMRI using 6 CO2 inhalation

Zappe, A.-C., Uludag, K., & Logothetis, N. (2008). Direct measurement of oxygen extraction with fMRI using 6 CO2 inhalation. Magnetic Resonance Imaging, 26(7), 961-967. doi:10.1016/j.mri.2008.02.005.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C705-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-E331-5
Genre: Journal Article

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Zappe, A-C1, 2, Author              
Uludag, K2, 3, Author              
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              

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 Abstract: The blood oxygenation level-dependent (BOLD) signal is an indirect hemodynamic signal which is sensitive to cerebral blood flow (CBF), cerebral blood volume (CBV) and cerebral metabolic rate of oxygen (CMRO2). Therefore, the BOLD signal amplitude and dynamics cannot be interpreted unambiguously without additional physiological measurements and, thus, there remains a need for a functional magnetic resonance imaging (fMRI) signal which is more closely related to the underlying neuronal activity. In this study, we measured cerebral blood flow with continuous arterial spin labeling, cerebral blood volume with an exogenous contrast agent and BOLD combined with intracortical electrophysiological recording in primary visual cortex of the anesthetized monkey. During inhalation of 6 CO2, it was observed that CBF and CBV are not further increased by a visual stimulus, although baseline CBF for 6 CO2 is below the maximal value of CBF. In contrast, the electrophysiological response to the stimulation was found to be preserved during hypercapnia. As a consequence, the simultaneously measured BOLD signal responds negatively to a visual stimulation for 6 CO2 inhalation in the same voxels responding positively during normocapnia. These observations suggest that the fMRI response to a sensory stimulus for 6 CO2 inhalation occurs in the absence of a hemodynamic response, and it therefore directly reflects the oxygen extraction into the tissue.

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 Dates: 2008-09
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.mri.2008.02.005
BibTex Citekey: 4918
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Title: Magnetic Resonance Imaging
Source Genre: Journal
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Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 26 (7) Sequence Number: - Start / End Page: 961 - 967 Identifier: ISSN: 0730-725X
CoNE: https://pure.mpg.de/cone/journals/resource/954925533026