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  Electric stimulation fMRI of the perforant pathway to the rat hippocampus

Canals, S., Beyerlein, M., Murayama, Y., & Logothetis, N. (2008). Electric stimulation fMRI of the perforant pathway to the rat hippocampus. Magnetic Resonance Imaging, 26(7), 978-986. doi:10.1016/j.mri.2008.02.018.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C70B-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-2D03-8
Genre: Journal Article

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 Creators:
Canals, S1, 2, Author              
Beyerlein, M1, 2, Author              
Murayama, Y1, 2, Author              
Logothetis, NK1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: The hippocampal formation is a brain system that is implicated in learning and memory. The major input to the hippocampus arrives from the entorhinal cortex (EC) to the dentate gyrus (DG) through the perforant path. In the present work, we have investigated the functional properties of this connection by concomitantly applying electrophysiological techniques, deep-brain electric microstimulation and functional magnetic resonance imaging in anesthetized rats. We systematically delivered different current intensities at diverse stimulation frequencies to the perforant path while recording electrophysiological and blood-oxygenation-level-dependent (BOLD) signals. We observed a linear relationship between the current intensity used to stimulate the hippocampal formation and the amplitude and extension of the induced BOLD response. In addition, we found a frequency-dependent spatial pattern of activation. With stimulation protocols and train frequencies used for kindling, the activity strongly spreads ipsilaterall y through the hippocampus, DG, subiculum and EC.

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 Dates: 2008-09
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.mri.2008.02.018
BibTex Citekey: 4909
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Title: Magnetic Resonance Imaging
Source Genre: Journal
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Affiliations:
Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 26 (7) Sequence Number: - Start / End Page: 978 - 986 Identifier: ISSN: 0730-725X
CoNE: https://pure.mpg.de/cone/journals/resource/954925533026