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  Smart MRI Agents Sensing Extracellular Calcium Fluctuations

Angelovski, G., Fousková, P., Mamedov, I., Canals, S., Tóth, É., & Logothetis, N. (2008). Smart MRI Agents Sensing Extracellular Calcium Fluctuations. Poster presented at 2008 World Molecular Imaging Congress (WMIC), Nice, France.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C777-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-8BA3-8
Genre: Poster

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WMIC-2008-Angelovski.pdf (Abstract), 97KB
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Angelovski, G1, 2, Author              
Fousková, P, Author
Mamedov, I1, 2, Author              
Canals, S1, 2, Author              
Tóth, É, Author
Logothetis, NK1, 2, Author              
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1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Functional Magnetic Resonance Imaging (fMRI) is currently the main tool used for the study of function and dysfunction of the human brain. The current mainstay of fMRI, the so-called Blood-Oxygen-Level-Dependent (BOLD) contrast, capitalizes on the detection of changes in cerebral blood flow, volume and oxygenation, but cannot directly report neural activity, as it suffers from poor spatiotemporal resolution and specificity compared to the actual neural events. An alternative methodology could be that relying on the responsive, ‘smart’ contrast agents whose relaxivity depends on the concentration of substances directly related to neuronal activity. Ca2+ is an excellent marker closely linked to brain activation and is preferred target for various imaging methods. We report two Gd3+ chelates linked to a modified EGTA moiety that have a relaxivity response to extracellular Ca2+ fluctuations in the brain. The proton relaxivity of both Gd3+ complexes is sensitive to the variation of Ca2+ concentration. They are selective to Ca2+ with respect to the main competitor cation Mg2+. Upon interaction with Ca2+, the complexes exhibit high and reversible relaxivity changes; the relaxivity response of one complex upon addition of Ca2+ exceeds 80. Moreover, the relaxivity changes remain remarkable (>50) even in the medium mimicking the brain extracellular fluid, exhibiting a ~10 relaxivity change in the physiologically relevant Ca2+ concentration range (changes induced during the neural activity). These agents have great potential to be applied as functional MR markers and be used for the visualization of the neural processes. They can substantially increase the specificity and spatial resolution of the MR-detected signals and open new perspectives in fMRI.

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 Dates: 2008-09
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: 5468
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Title: 2008 World Molecular Imaging Congress (WMIC)
Place of Event: Nice, France
Start-/End Date: 2008-09-10 - 2008-09-13

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Title: 2008 World Molecular Imaging Congress (WMIC)
Source Genre: Proceedings
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