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  Predicting phenotypic effects of gene perturbations in C. elegans using an integrated network model

Borgwardt, K. (2008). Predicting phenotypic effects of gene perturbations in C. elegans using an integrated network model. Bioessays, 30(8), 707-710. doi:10.1002/bies.20783.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C78F-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-2FD3-B
Genre: Journal Article

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Borgwardt, K1, Author              
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 Abstract: Predicting the phenotype of an organism from its genotype is a central question in genetics. Most importantly, we would like to find out if the perturbation of a single gene may be the cause of a disease. However, our current ability to predict the phenotypic effects of perturbations of individual genes is limited. Network models of genes are one tool for tackling this problem. In a recent study, (Lee et al.) it has been shown that network models covering the majority of genes of an organism can be used for accurately predicting phenotypic effects of gene perturbations in multicellular organisms.

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 Dates: 2008-08
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/bies.20783
BibTex Citekey: Borgwardt2008
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Title: Bioessays
  Other : Bioessays
Source Genre: Journal
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Publ. Info: Cambridge, UK : Co. of Biologists
Pages: - Volume / Issue: 30 (8) Sequence Number: - Start / End Page: 707 - 710 Identifier: ISSN: 0265-9247
CoNE: https://pure.mpg.de/cone/journals/resource/954925499109