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  Covalent Pyrenebutyrate-Cell Penetrating Peptide Conjugates: Enhanced Direct Membrane Translocation of Coupled Molecular Imaging Agents

Mishra, R., Su, W., Pfeuffer, J., Ugurbil, K., & Engelmann, J. (2009). Covalent Pyrenebutyrate-Cell Penetrating Peptide Conjugates: Enhanced Direct Membrane Translocation of Coupled Molecular Imaging Agents. In 35th Annual Meeting and Exposition of the Controlled Release Society 2008 (pp. 817-818). Red Hook, NY, USA: Curran.

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 Creators:
Mishra, R1, 2, Author           
Su, W1, 2, Author           
Pfeuffer, J2, 3, Author           
Ugurbil, K, Author
Engelmann, J1, 2, Author           
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: Intracellular targeting with cell penetrating
peptides (CPPs) is limited by endocytotic
mechanism of uptake. Here, we report that
the well known CPP, dTat, chemically
coupled with pyrenebutyrate (PB) can
efficiently deliver directly into the cytosol.
Results indicate that this combination could
successfully translocate magnetic resonance imaging (MRI) agents into cytosol.

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 Dates: 2008-072009-02
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: BibTex Citekey: 5150
 Degree: -

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Title: 35th Annual Meeting and Exposition of the Controlled Release Society 2008
Place of Event: New York, NY, USA
Start-/End Date: 2008-07-12 - 2008-07-16

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Title: 35th Annual Meeting and Exposition of the Controlled Release Society 2008
Source Genre: Proceedings
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Publ. Info: Red Hook, NY, USA : Curran
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 817 - 818 Identifier: ISBN: 978-1-60560-635-4