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  Population imaging of ongoing neuronal activity in the visual cortex of awake rats

Greenberg, D., Houweling, A., & Kerr, J. (2008). Population imaging of ongoing neuronal activity in the visual cortex of awake rats. Nature Neuroscience, 11(7), 749-751. doi:10.1038/nn.2140.

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https://www.nature.com/articles/nn.2140.pdf (Publisher version)
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Greenberg, DS1, 2, 3, Author              
Houweling, AR, Author
Kerr, JND1, 2, 3, Author              
Affiliations:
1Former Research Group Network Imaging, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528697              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Research Group Neural Population Imaging, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497807              

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 Abstract: It is unclear how the complex spatiotemporal organization of ongoing cortical neuronal activity recorded in anesthetized animals relates to the awake animal. We therefore used two-photon population calcium imaging in awake and subsequently anesthetized rats to follow action potential firing in populations of neurons across brain states, and examined how single neurons contributed to population activity. Firing rates and spike bursting in awake rats were higher, and pair-wise correlations were lower, compared with anesthetized rats. Anesthesia modulated population-wide synchronization and the relationship between firing rate and correlation. Overall, brain activity during wakefulness cannot be inferred using anesthesia.

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 Dates: 2008-06
 Publication Status: Published in print
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 Identifiers: DOI: 10.1038/nn.2140
BibTex Citekey: 5236
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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 11 (7) Sequence Number: - Start / End Page: 749 - 751 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931