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  1H MR Spectroscopic Measurement of Neurochemical Alterations in the Hippocampus of a Rat Model of Depression

Hong, S.-T., Choi, C.-B., Choe, B.-Y., Park, C., Hong, G., & Chae, J.-H. (2008). 1H MR Spectroscopic Measurement of Neurochemical Alterations in the Hippocampus of a Rat Model of Depression. Poster presented at 16th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008), Toronto, Canada.

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Hong, S-T1, 2, Author              
Choi , C-B, Author
Choe, B-Y, Author
Park, C, Author
Hong, G, Author
Chae, J-H, Author
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: The forced swimming test (FST) is considered one of the most widely used and reliable animal models of depression for the assessment of antidepressant activity and for examining the pathophysiology of depression pre-clinically [1]. The impaired synaptic efficacy due to the FST procedure involving severe physical and emotional stress has been reported in the rat hippocampus, and the synaptic efficacy shows significant improvement after being treated with repetitive transcranial magnetic stimulation (rTMS) [2]. We recently reported a significantly increased Cho/Cr ratio in the dorsolateral pre-frontal cortex (DLPFC) of rats exposed to the FST compared with control animals [3], which is similar to results obtained from investigations of patients with depression [4]. To extend our previous findings and characterize the variation of the hippocampal Cho/Cr ratio in an animal model of depression, we systematically examined the Cho/Cr ratio in the hippocampus of rats exposed to the FST and controls by using relatively small volume-of-interest (VOI) compared with our previous study that specifically focused on the homogeneous hippocampus tissue.

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 Dates: 2008-05
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: HongCCPHC2008
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Title: 16th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008)
Place of Event: Toronto, Canada
Start-/End Date: 2008-05-03 - 2008-05-09

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Title: 16th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 2332 Start / End Page: 386 Identifier: -