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  Pharmacological MRI combined with electrophysiology in non-human primates: Effects of Lidocaine on primary visual cortex

Rauch, A., Rainer, G., Augath, M., Oeltermann, A., & Logothetis, N. (2008). Pharmacological MRI combined with electrophysiology in non-human primates: Effects of Lidocaine on primary visual cortex. NeuroImage, 40(2), 590-600. doi:10.1016/j.neuroimage.2007.12.009.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C9CD-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-3116-D
Genre: Journal Article

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Rauch, A1, 2, Author              
Rainer, G1, 2, Author              
Augath, M1, 2, Author              
Oeltermann, A1, 2, Author              
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Pharmacological magnetic resonance imaging (phMRI) is a current direction in biomedical imaging, whose goal is the non-invasive monitoring of pharmacological manipulations on brain processes. We have developed techniques combining phMRI with simultaneous monitoring of electrophysiological activity during local injections of pharmacological agents into defined brain regions. We have studied effects of the local anesthetic Lidocaine on BOLD activity in primary visual cortex (V1) of non-human primates. Using independent component analysis (ICA), we describe and quantify the pharmacodynamics and spatial distribution of Lidocaine effects on visually evoked V1 BOLD signal in a dose-dependent manner. We relate these findings to effects of Lidocaine on neural activity as estimated by multi unit activity (MUA) and the local field potential (LFP). Our results open the way for specific fMRI-based investigations regarding the impact of pharmacological agents on the BOLD signal and its coupling to the underlying neuronal activity.

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 Dates: 2008-04
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.neuroimage.2007.12.009
BibTex Citekey: 4951
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 40 (2) Sequence Number: - Start / End Page: 590 - 600 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166