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  Simultaneous PET-MRI: a new approach for functional and morphological imaging

Judenhofer, M., Wehrl, H., Newport, D., Catana, C., Siegel, S., Becker, M., et al. (2008). Simultaneous PET-MRI: a new approach for functional and morphological imaging. Nature Medicine, 14(4), 459-465. doi:10.1038/nm1700.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C9D1-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-3125-C
Genre: Journal Article

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https://www.nature.com/articles/nm1700.pdf (Publisher version)
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 Creators:
Judenhofer, MS, Author
Wehrl, HF, Author
Newport, DF, Author
Catana, C, Author
Siegel, SB, Author
Becker, M, Author
Thielscher, A1, 2, Author              
Kneiling, M, Author
Lichy, MP, Author
Eichner, M, Author
Klingel, K, Author
Reischl, G, Author
Widmaier, S, Author
Röcken, M, Author
Nutt, RE, Author
Machulla, H-J, Author
Uludag, K1, 2, Author              
Cherry, SR, Author
Claussen, CD, Author
Pichler, BJ, Author
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Noninvasive imaging at the molecular level is an emerging field in biomedical research. This paper introduces a new technology synergizing two leading imaging methodologies: positron emission tomography (PET) and magnetic resonance imaging (MRI). Although the value of PET lies in its high-sensitivity tracking of biomarkers in vivo, it lacks resolving morphology. MRI has lower sensitivity, but produces high soft-tissue contrast and provides spectroscopic information and functional MRI (fMRI). We have developed a three-dimensional animal PET scanner that is built into a 7-T MRI. Our evaluations show that both modalities preserve their functionality, even when operated isochronously. With this combined imaging system, we simultaneously acquired functional and morphological PET-MRI data from living mice. PET-MRI provides a powerful tool for studying biology and pathology in preclinical research and has great potential for clinical applications. Combining fMRI and spectroscopy with PET paves the way for a new perspective in molecular imaging.

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 Dates: 2008-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/nm1700
BibTex Citekey: 5386
 Degree: -

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Title: Nature Medicine
  Other : Nat. Med.
Source Genre: Journal
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Publ. Info: New York, NY : Nature Pub. Co.
Pages: - Volume / Issue: 14 (4) Sequence Number: - Start / End Page: 459 - 465 Identifier: ISSN: 1078-8956
CoNE: https://pure.mpg.de/cone/journals/resource/954925606824