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  Sustained increase in hippocampal sharp-wave ripple activity during slow-wave sleep after learning

Eschenko, O., Ramadan, W., Mölle, W., Born, J., & Sara, S. (2008). Sustained increase in hippocampal sharp-wave ripple activity during slow-wave sleep after learning. Learning & memory, 15(4), 222-228. doi:10.1101/lm.726008.

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Eschenko, O1, Author              
Ramadan, W, Author
Mölle, W, Author
Born, J, Author
Sara, SJ, Author
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1External Organizations, ou_persistent22              

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 Abstract: High-frequency oscillations, known as sharp-wave/ripple (SPW-R) complexes occurring in hippocampus during slow-wave sleep (SWS), have been proposed to promote synaptic plasticity necessary for memory consolidation. We recorded sleep for 3 h after rats were trained on an odor-reward association task. Learning resulted in an increased number SPW-Rs during the first hour of post-learning SWS. The magnitude of ripple events and their duration were also elevated for up to 2 h after the newly formed memory. Rats that did not learn the discrimination during the training session did not show any change in SPW-Rs. Successful retrieval from remote memory was likewise accompanied by an increase in SPW-R density and magnitude, relative to the previously recorded baseline, but the effects were much shorter lasting and did not include increases in ripple duration and amplitude. A short-lasting increase of ripple activity was also observed when rats were rewarded for performing a motor component of the task only. There were no increases in ripple activity after habituation to the experimental environment. These experiments show that the characteristics of hippocampal high-frequency oscillations during SWS are affected by prior behavioral experience. Associative learning induces robust and sustained (up to 2 h) changes in several SPW-R characteristics, while after retrieval from remote memory or performance of a well-trained procedural aspect of the task, only transient changes in ripple density were induced.

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 Dates: 2008-04
 Publication Status: Published in print
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 Identifiers: DOI: 10.1101/lm.726008
BibTex Citekey: 5196
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Title: Learning & memory
Source Genre: Journal
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Publ. Info: Cold Spring Harbor Laboratory Press
Pages: - Volume / Issue: 15 (4) Sequence Number: - Start / End Page: 222 - 228 Identifier: ISSN: 1072-0502
CoNE: https://pure.mpg.de/cone/journals/resource/954925603751