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  GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI

Northoff, G., Walter, M., Schulte, R., Beck, J., Dydak, U., Henning, A., et al. (2007). GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI. Nature Neuroscience, 10(12), 1515-1517. doi:10.1038/nn2001.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-CAE5-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B9B9-C
Genre: Journal Article

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Northoff, G, Author
Walter, M1, Author              
Schulte, RF, Author
Beck, J, Author
Dydak, U, Author
Henning, A1, Author              
Boeker, H, Author
Grimm, S, Author
Boesiger, P, Author
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1External Organizations, ou_persistent22              

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 Abstract: The human anterior cingulate cortex (ACC) is part of the default-mode network that shows predominant negative blood oxygen level–dependent (BOLD) responses in functional magnetic resonance imaging (fMRI). We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy measurements and observed that the concentration of GABA in the ACC specifically correlated with the amount of negative BOLD responses in the very same region. Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA.

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 Dates: 2007-12
 Publication Status: Published in print
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1038/nn2001
BibTex Citekey: NorthoffWSBDHBGB2007
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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 10 (12) Sequence Number: - Start / End Page: 1515 - 1517 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931